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首页> 外文期刊>International Journal of Research in Medical Sciences >An updated overview of immune complex mediated rheumatoid arthritis
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An updated overview of immune complex mediated rheumatoid arthritis

机译：免疫复合物介导的类风湿关节炎的最新概述

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Rheumatoid arthritis is a widely known autoimmune disorder which affects the joints and cause major disability in affected population. Even though more emphasis is given in the western world for autoimmune research, people in developing countries are also suffering significantly due to autoimmune arthritis. This review is focused on the updates in rheumatoid arthritis research and developments in therapeutic strategies. The exact cause of this disease is unknown but primary cause for inflammatory changes in the joints are considered due to cytokine network imbalance and correcting this imbalance possibly will cure the disease. Using this knowledge the newer therapeutic approaches to rheumatoid arthritis are being aimed at correcting this imbalance. Recently three most promising therapeutic products appear to be the use of monoclonal antibodies to TNF-α, soluble TNF-α receptors, and IL-1 receptor antagonist. Other therapeutic agents that could regulate the cytokine network are in various stages of laboratory and clinical evaluation. But the need to study the causative factor and prognostic marker along with other approaches is much more important to prevent clinical remission and for the complete cure of the disease. This review highlights the important recent breakthrough in the field and some suggestions for significant basic research.
机译：类风湿关节炎是一种广为人知的自身免疫性疾病，它会影响关节并导致受影响人群的严重残疾。尽管西方国家更加重视自身免疫研究，但发展中国家的人们也因自身免疫性关节炎而遭受巨大痛苦。这篇综述着重于类风湿关节炎研究的发展和治疗策略的发展。该疾病的确切原因尚不清楚，但由于细胞因子网络失衡，认为是关节中炎症变化的主要原因，纠正这种失衡可能会治愈该疾病。利用这些知识，针对类风湿关节炎的新型治疗方法旨在纠正这种失衡。最近，三种最有希望的治疗产品似乎是使用针对TNF-α，可溶性TNF-α受体和IL-1受体拮抗剂的单克隆抗体。可以调节细胞因子网络的其他治疗剂处于实验室和临床评估的各个阶段。但是，研究病因和预后标志物以及其他方法，对于预防临床缓解和彻底治愈该疾病更为重要。这篇综述着重介绍了该领域最近的重要突破，并对重要的基础研究提出了一些建议。

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