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首页> 外文期刊>International Journal of Research in Medical Sciences >Crimean-Congo haemorrhagic fever: an overview
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Crimean-Congo haemorrhagic fever: an overview

机译：克里米亚-刚果出血热概述

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Crimean-Congo Hemorrhagic Fever (CCHF) is an acute, highly-contagious and life-threatening vector borne disease. The CCHF virus causes severe viral hemorrhagic fever outbreaks, with a case fatality rate of 10-40%. CCHF virus isolation and/or disease has been reported from more than 30 countries in Africa, Asia, South eastern Europe and Middle east. Jan 2011 marks first ever reports of outbreak of CCHF in India, total 5 cases were detected of CCHF from Gujarat. CCHF has recently in news again, 6 human cases and 32 animal samples test positive for CCHF from Kariyana village of Amreli district (Gujarat state) July 2013. Crimean-Congo hemorrhagic fever virus (CCHFV), member of genus Nairovirus in the family Bunyaviridae. Numerous genera of ixodid ticks serve both as vector and reservoir for CCHFV. Human infections occurred through tick bites, direct contact with blood or tissue of infected livestock, or nosocomial infections. Human infections begin with nonspecific febrile symptoms, but progress to a serious hemorrhagic syndrome with a high case fatality ratio. The most definitive way of diagnosis is the demonstration of virus or viral genome in sera samples. Hospitalization in special care unit with constant effort to prevent haemorrhagic complication along with laboratory monitoring is cornerstone for treatment of CCHF. Till date there is no FDA approved drug or definitive treatment for CCHF, ribavirin is tried by many physician need to be evaluated further. Current article is an effort to update existing knowledge about CCHF by due focus on various aspects especially prevention of this zoonotic disease. Much of the real life queries about this disease are elaborated after extensive literature research.
机译：克里米亚-刚果出血热（CCHF）是一种急性，高传染性和威胁生命的媒介传播疾病。 CCHF病毒引起严重的病毒性出血热暴发，病死率为10-40％。非洲，亚洲，东南欧和中东的30多个国家已经报告了CCHF病毒的分离和/或疾病。 2011年1月是印度有史以来首例CCHF爆发的报告，总共从古吉拉特邦发现了5例CCHF。 CCHF最近又有新闻报道，2013年7月，来自古吉拉特邦Amreli区Kariyana村的6例人类病例和32个动物样本的CCHF呈阳性。克里米亚-刚果出血热病毒（CCHFV），属于Bunyaviridae内罗病毒属。 ixodid s的许多属既作为CCHFV的载体又作为贮藏库。人感染是通过叮咬，直接接触被感染牲畜的血液或组织或医院感染而发生的。人的感染始于非特异性的发热症状，但发展为严重的出血综合征，病死率高。最明确的诊断方法是在血清样本中显示病毒或病毒基因组。持续不断地努力预防出血性并发症的特殊护理部门的住院治疗以及实验室监测是CCHF治疗的基石。迄今为止，尚无FDA批准的CCHF药物或权威性治疗方法，许多医生尝试使用利巴韦林，需要进一步评估。本文旨在通过适当关注各个方面（尤其是预防这种人畜共患疾病）来更新有关CCHF的现有知识。经过广泛的文献研究，许多关于这种疾病的现实生活疑问都得到了详细阐述。

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