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首页> 外文期刊>International Journal of Research in Medical Sciences >Role of urine sediment cytology in the diagnosis of renal disorders in comparison with biochemical and histopathological findings
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Role of urine sediment cytology in the diagnosis of renal disorders in comparison with biochemical and histopathological findings

机译：与生化和组织病理学发现相比，尿沉渣细胞学在肾脏疾病诊断中的作用

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Background: The functional reserve of the kidney being large, serum biochemical parameters do not show abnormality until late. The need to recognize minimal damage in the kidneys is hence valuable. Urine sediment examination is cost effective, time saving and is called "liquid renal biopsy". The present study was aimed to evaluate the role of urine sediment examination in predicting the severity of renal damage and compare the results with serum biochemical parameters, 24 hour urine protein values and renal biopsy findings. Methods: A total of 149 patients presenting with symptoms pertaining to renal disease were included in the study. Clinical information and serum biochemical parameters were obtained. Urine examination was done and renal biopsy performed in all the cases. 2 scoring systems were adopted to grade the urine sediment findings and renal biopsy grading devised by A. Z. Gyory et al. was used to grade the renal injury. 24 hour urine protein was estimated by Esbach's method. Urine sediment scores, serum biochemical parameters, 24 hour urine protein values were compared with the grades of renal injury on renal biopsies and statistical significance calculated. Results: 32.8% of patients with renal disease were in the age group of 31-40 years. Nephrotic syndrome was the most common clinical presentation (33.5%) followed by nephritic syndrome (21.4%). The most common histopathological diagnosis was post infectious glomerulonephritis (n = 26) followed by acute interstitial nephritis (n = 17). 14 cases of lupus nephritis were diagnosed all of which were confirmed by "full house" pattern of immunofluorescence. Both the urine sediment scores had high specificity and positive predictive values in predicting the severity of renal injury. 24 hour urine protein had high positive predictive value in predicting the severity of renal injury. Serum biochemical parameters were insignificant in predicting the severity of renal injury. Conclusion: Urine sediment examination can be used as an effective diagnostic test for predicting the severity of renal injury. The decision of further investigations and follow-up can be certainly decided by taking urine microscopy findings and 24 hour urine protein values into consideration.
机译：背景：肾脏的功能储备很大，血清生化指标直到晚期才显示异常。因此，认识到肾脏的最小损伤的需求很重要。尿沉渣检查具有成本效益，节省时间的特点，被称为“液体肾活检”。本研究旨在评估尿沉渣检查在预测肾脏损害严重程度中的作用，并将结果与​​血清生化参数，24小时尿蛋白值和肾活检结果进行比较。方法：共有149例表现出与肾脏疾病有关的症状的患者被纳入研究。获得临床信息和血清生化参数。所有病例均进行了尿液检查并进行了肾脏活检。 A. Z. Gyory等人设计的2种评分系统对尿沉渣发现和肾脏活检分级进行评分。用于对肾损伤进行分级。通过Esbach方法估计24小时尿蛋白。将尿沉渣评分，血清生化参数，24小时尿蛋白值与肾活检中肾损伤的等级进行比较，并计算统计学意义。结果：32.8％的肾病患者年龄在31-40岁之间。肾病综合征是最常见的临床表现（33.5％），其次是肾病综合征（21.4％）。最常见的组织病理学诊断是感染后肾小球肾炎（n = 26），然后是急性间质性肾炎（n = 17）。诊断出14例狼疮性肾炎，所有这些都通过免疫荧光的“满屋子”模式得到证实。尿沉渣评分在预测肾损伤的严重程度时均具有高特异性和阳性预测值。 24小时尿蛋白在预测肾损伤的严重程度方面具有较高的阳性预测价值。血清生化参数在预测肾损伤的严重程度方面意义不大。结论：尿沉渣检查可作为预测肾损伤严重程度的有效诊断方法。可以通过考虑尿液显微镜检查结果和24小时尿蛋白值来确定进一步调查和随访的决定。

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