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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >A prospective study of efficacy and safety of mifepristone and vaginal misoprostol in termination of pregnancy up to 63 days of gestation
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A prospective study of efficacy and safety of mifepristone and vaginal misoprostol in termination of pregnancy up to 63 days of gestation

机译：米非司酮和阴道米索前列醇终止妊娠至妊娠63天的有效性和安全性的前瞻性研究

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Background: Illegal abortion is still one of the important causes of maternal mortality in India accounting for approximately 13%. Medical Management of abortion is a non-surgical termination which does not require special facilities like operation theatre, hospital stay and thereby reduces complications associated with the same. Methods: It is a prospective study done in a Tertiary care Government Hospital over a span from Jan 2015 to April 2016. After patient selection as per inclusion criteria and written informed consent after evaluating patients were enrolled in the study. In first visit Tab. mifepristone 200 mg. orally was given and advised to take Tab. misoprostol 800 mcg. Vaginally after 48 hours at home. They were counselled for side effects and asked to report in case of excess bleeding, pain, fever or no bleed for 24 hours of misoprostol. After 7 days follow up was done to ensure completion of abortion. Any additional drugs required were noted. Contraceptive advice is also given during these visits. Results: In our study 60 cases were taken. Majority of women are between 20-29 years of age which is peak reproductive age. 61.1% women are of second parity. The success rate of medical methods is 96.6%, two cases out of 60 underwent surgical evacuation and one was lost to follow up. Most common adverse effect noted is abdominal cramps. No patient required hospitalization. Additional Misoprostol was required in 4 cases. This method is highly acceptable 95% cases as it is non invasive and preferred to adopt the same in future if needed. Conclusions: Patient participation, motivation, compliance, regular follow up visits, ability to record and report complications are the pillars on which the success of medical methods depends. Hence overall, it came out to be safe and effective method.
机译：背景：非法堕胎仍然是印度孕产妇死亡的重要原因之一，约占13％。堕胎的医学管理是非手术终止，不需要手术室，住院等特殊设施，从而减少了与此相关的并发症。方法：这是一项前瞻性研究，于2015年1月至2016年4月期间在三级政府医院进行。根据入选标准选择患者并评估患者后，签署知情同意书。在第一次访问选项卡。米非司酮200毫克。口服，建议服用Tab。米索前列醇800 mcg。 48小时后在家中。对他们的副作用进行了咨询，并要求他们在米索前列醇24小时过量出血，疼痛，发烧或无出血的情况下进行报告。 7天后进行随访以确保流产完成。记录了所需的任何其他药物。在这些访问期间，还会提供避孕建议。结果：本研究共收治60例。大多数妇女年龄在20-29岁之间，这是生殖高峰。 61.1％的女性处于次等地位。医疗方法的成功率为96.6％，其中60例中有2例接受了手术疏散，其中1例失去了随访。最常见的不良反应是腹部绞痛。没有患者需要住院。 4例还需要米索前列醇。此方法在95％的情况下是高度可接受的，因为它是非侵入性的，并且在将来需要时最好采用这种方法。结论：患者的参与，动机，依从性，定期随访，记录和报告并发症的能力是医疗方法成功的基础。因此，总的来说，它是一种安全有效的方法。

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