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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Efficacy of combination of tablet mifepristone and misoprostol for first trimester pregnancy termination at different gestational age
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Efficacy of combination of tablet mifepristone and misoprostol for first trimester pregnancy termination at different gestational age

机译：米非司酮片和米索前列醇联合用药在不同胎龄早孕中止的疗效

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Background: Medical method of abortion is a safe, effective and affordable method for first trimester termination. However, nausea, vomiting, diarhoea, excess bleeding and incomplete abortion are known side effects. The aim of study was to compare the success rate of abortions in both groups, to compare the induction-abortion interval in both groups and to study the side effects of the drugs. Methods: This study was conducted in department of obstetrics and gynecology, NIMS Medical College, Jaipur, India during June 2017-August 2017. Total hundred cases were taken and divided into two groups. Group A was gestational age upto 49 days, Group B was gestational age 50-63 days. Both groups were given tab. mifepristone 200mg. followed by 48 hrs. by 4 tablets of tab misoprostol. Results: The results of the given regimen were highly successful and complete abortion was achieved in 96% and 94% in group A and group B respectively. The difference between two groups was statistically not significant (p value =0.64). Failure rates were seen in only 4% of group A and 6% of group B. Pain abdomen was seen in 16% of group A and 38% of group B patients. The difference between both groups was statistically significant (p value=0.02). Nausea was seen in 10% of group A and 30% of group B patients. The difference between both groups is statistically significant(p value=0.018). Conclusions: First trimester pregnancy can be successfully terminated with combination of mifepristone and misoprostol upto 63 days (9 weeks) of pregnancy.
机译：背景：医学流产方法是终止早孕的安全，有效和负担得起的方法。但是，恶心，呕吐，腹泻，出血过多和流产不完全是已知的副作用。研究的目的是比较两组的堕胎成功率，比较两组的堕胎间隔和研究药物的副作用。方法：本研究于2017年6月至2017年8月在印度斋浦尔市NIMS医学院妇产科进行。共收治100例病例，分为两组。 A组的胎龄不超过49天，B组的胎龄为50-63天。两组都被赋予标签。米非司酮200mg。随后48小时。通过4片米索前列醇片。结果：给定方案的结果非常成功，A组和B组分别达到96％和94％的完全流产。两组之间的差异无统计学意义（p值= 0.64）。仅在A组的4％和B组的6％观察到失败率。在A组的16％和B组的38％的患者中观察到腹部疼痛。两组之间的差异具有统计学意义（p值= 0.02）。 A组10％的患者和B组30％的患者出现恶心。两组之间的差异具有统计学意义（p值= 0.018）。结论：米非司酮和米索前列醇合用可在妊娠63天（9周）内成功终止早孕。

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