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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Comparative evaluation of NESTROFT and RDW as screening tests for beta thalassemia trait in pregnancy
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Comparative evaluation of NESTROFT and RDW as screening tests for beta thalassemia trait in pregnancy

机译：NESTROFT和RDW作为妊娠β地中海贫血性格筛查测试的比较评价

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Background: Thalassemia is the commonest inherited hemoglobinopathy. It is estimated that there are about 45 million carriers of the beta thalassemia gene and about 15000 affected infants are born every year in India, thereby contributing to about 10% of the total thalassemia babies born all over the world. Beta Thalassemia Trait (BTT) is asymptomatic while Beta Thalassemia Major (BTM) presents with severe anemia and requires lifelong blood transfusion, so emphasis must shift from treatment to screening and offering prenatal counseling to affected parents. Methods: It was a hospital based cross sectional study on 500 antenatal women with microcytic hypochromic anemia with hemoglobin Results: In our study the sensitivity and specificity of NESTROFT was 93.3% and 95.7% respectively compared to Red cell Distribution Width (RDW) with a sensitivity and specificity of 66.6% and 78.9% respectively. Conclusions: For low resource settings like India, screening for beta thalassemia by NESTROFT is a cheaper and more reliable method with a high sensitivity and specificity and can be performed easily by paramedical staff.
机译：背景：地中海贫血是最常见的遗传性血红蛋白病。据估计，印度每年约有4,500万的β地中海贫血基因携带者，约有15,000名受影响的婴儿出生，从而占全世界出生的地中海贫血婴儿的约10％。 Beta地中海贫血特征（BTT）无症状，而严重Beta地中海贫血（BTM）表现为严重贫血，需要终身输血，因此重点必须从治疗转向筛查，并向患病父母提供产前咨询。方法：这是一项基于医院的横断面研究，对500名患有血红蛋白的小细胞性低色素性贫血的产前妇女进行了结果。在本研究中，NESTROFT的敏感性和特异性分别为93.3％和95.7％，而具有敏感性的红细胞分布宽度（RDW）特异性分别为66.6％和78.9％。结论：对于印度这样的资源贫乏地区，NESTROFT筛查β地中海贫血是一种更便宜，更可靠的方法，具有高灵敏度和特异性，并且可以由医护人员轻松进行。

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