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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Hypothyroidism in polycystic ovarian syndrome: a comparative study of clinical characteristics, metabolic and hormonal parameters in euthyroid and hypothyroid polycystic ovarian syndrome women
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Hypothyroidism in polycystic ovarian syndrome: a comparative study of clinical characteristics, metabolic and hormonal parameters in euthyroid and hypothyroid polycystic ovarian syndrome women

机译：多囊卵巢综合征的甲状腺功能减退症：正常和甲状腺功能减退的多囊卵巢综合征女性的临床特征，代谢和激素参数的比较研究

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Background: This study was conducted to examine influence of hypothyroidism on pathophysiology and features of PCOS with respect to clinical characteristics of polycystic ovarian syndrome (PCOS), hormonal and metabolic profile. Methods: 102 euthyroid PCOS and 18 hypothyroid PCOS women were included in this cross-sectional study after considering inclusion and exclusion criteria. The study subjects were assessed for various signs and symptoms like recent weight gain, obesity, abnormal hair growth, hirsutism, hair loss, acne, acanthosis nigricans and infertility. Various hormonal and metabolic parameters were evaluated viz. Luteinizing hormone, Follicle stimulating hormone, LH:FSH ratio, testosterone, prolactin, dehydroepiandrosterone, fasting insulin and fasting blood glucose. BMI and HOMA values were calculated. Results: Association of hirsutism, excessive hair growth, hair loss, acanthosis nigricans, acne, infertility was not significant between the two groups. Majority of patients in both the groups were overweight/obese. BMI and number of patients complaining weight gain was significantly more in hypothyroid PCOS women. While no statistical difference in LH, FSH, LH:FSH ratio, prolactin, and testosterone levels was found, serum DHEA level was significantly less in hypothyroid PCOS group. No statistical difference in fasting blood glucose and insulin levels was found between the two groups. Though both the groups show insulin resistance, HOMA values were significantly more in hypothyroid PCOS women. Conclusions: Presence of hypothyroidism significantly increased severity of insulin resistance as well as obesity in PCOS. This could have adverse metabolic consequences in them. Concurrent occurrence of both these disorder could also possibly affect other features of the PCOS viz. hair loss and infertility.
机译：背景：本研究旨在检查甲状腺功能减退症对多囊卵巢综合征（PCOS）的临床特征，激素和代谢状况对PCOS病理生理和特征的影响。方法：在考虑纳入和排除标准后，本横断面研究纳入了102例甲状腺功能正常的PCOS和18例甲状腺功能低下的PCOS妇女。对研究对象进行了各种体征和症状评估，例如近期体重增加，肥胖，头发异常生长，多毛症，脱发，痤疮，黑棘皮症和不育症。评估了各种激素和代谢参数。黄体生成素，促卵泡激素，LH：FSH比，睾丸激素，催乳素，脱氢表雄酮，空腹胰岛素和空腹血糖。计算BMI和HOMA值。结果：两组之间的多毛症，过度的头发生长，脱发，黑棘皮病，痤疮，不育症的关联性不显着。两组中的大多数患者都是超重/肥胖。甲状腺功能低下的多囊卵巢综合征女性的BMI和抱怨体重增加的患者人数明显更多。虽然在甲状腺机能减退组中，LH，FSH，LH：FSH比，催乳素和睾丸激素水平没有统计学差异，但是血清DHEA水平明显低于甲状腺功能减退组。两组之间的空腹血糖和胰岛素水平无统计学差异。尽管两组均显示胰岛素抵抗，但甲状腺功能减退的多囊卵巢综合征妇女的HOMA值明显更高。结论：甲状腺功能减退症的存在显着增加了PCOS患者胰岛素抵抗和肥胖的严重程度。这可能会对他们产生不利的代谢后果。这两种疾病的同时发生也可能会影响PCOS的其他功能。脱发和不育。

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