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首页> 外文期刊>International journal of rheumatology >Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement
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Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement

机译：在HLA-B27 +强直性脊柱炎患者的髋关节受累滑膜中观察到异位生殖中心和产生IgG4的纤溶酶

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Introduction. Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases. This study aims to investigate hip synovial tissues of ankylosing spondylitis (AS) patients for IgG4-positive plasma cells and ectopic lymphoid tissues with germinal centers (GCs).Methods. Synovial samples were collected from 7 AS patients who received total hip replacement and were evaluated using immunohistochemistry for the presence of CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic cells (FDC), and CD38+ plasma cells. Furthermore, immunoglobulin G (IgG and IgG4), IgA, IgM, and complement components C3d and C4d in synovia were evaluated. Both synovial CD21+ FDCs and IgG4-producing plasmacytes were analyzed.Results. All seven patients had severe fibrosis. Massive infiltrations of lymphocytes were found in 5 out of 7 patients’ synovia. Ectopic lymphoid tissues with CD21+ FDC networks and IgG4-positive plasma cells were observed coincidentally in two patients’ synovia.Conclusion. The pathophysiological mechanism of AS patients’ hip damage might be related to the coincidental presence of ectopic lymphoid tissue with FDCs network and IgG4-positive plasma cells identified here for the first time in AS patients’ inflamed synovial tissue.
机译：介绍。在慢性炎症性硬化疾病中，已经证实了异位淋巴新生和IgG4阳性浆细胞的存在。这项研究旨在调查强直性脊柱炎（AS）患者的髋滑膜组织的IgG4阳性浆细胞和具有生发中心（GC）的异位淋巴组织。从7名接受全髋置换的AS患者中收集滑膜样品，并使用免疫组织化学方法评估其CD20 + B细胞，CD3 + T细胞，CD21 +滤泡树突状细胞（FDC）和CD38 +浆细胞的存在。此外，评估了滑膜中的免疫球蛋白G（IgG和IgG4），IgA，IgM和补体成分C3d和C4d。分析了滑膜CD21 + FDC和产生IgG4的浆细胞。所有七名患者均患有严重的纤维化。 7例滑膜中有5例发现淋巴细胞大量浸润。在两名患者的滑膜上同时发现了具有CD21 + FDC网络和IgG4阳性浆细胞的异位淋巴组织。 AS患者髋关节损伤的病理生理机制可能与同时存在FDCs网络的异位淋巴组织和AS患者炎症性滑膜组织中IgG4阳性浆细胞的同时存在有关。

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