...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of rheumatology >Familial Mediterranean Fever in Iran: A Report from FMF Registration Center
【24h】

Familial Mediterranean Fever in Iran: A Report from FMF Registration Center

机译：伊朗的家族性地中海热：FMF注册中心的报告

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Familial Mediterranean fever (FMF) is a periodic AR autoinflammatory disorder. This comprehensive study describes FMF in Iran as a country near Mediterranean area.Materials and Methods. From the country FMF registration center 403 patients according to Tel-Hashomer criteria enrolled this study, 239 patients had MEFV gene mutations analyses. Data, if needed, was analyzed by SPSS v20.Results. 175 patients (43.4%) were female and 228 patients (56.6%) were male. The mean age was 21.3 years. Abdominal pain was in 93.3% patients and 88.1% had fever. Abdominal pain was the main complaint of patients in (49.6%). The mean interval between attacks was36.5±29.6days and the mean duration of every episodes was43.3±34.5hours. 15.1% of patients had positive family history and 12.7% had previous surgery; in 52.3% of patients delay in diagnosis was more than three years. 12 common MEFV gene mutations were analyzed, 21.33% were without mutations, 39.7% had compound heterozygote, 25.52% showed heterozygous, and 13.38% showed homozygous results. The most common compound genotype was M694V-V726A (% 10.46) and in alleles M694V (% 20.9) and V726A (% 12.7) were the most frequent mutations, respectively.Conclusion. M694V was the most common mutation, and the most common compound genotype was M694V-V726A. Our genotype results are similar to Arabs and in some way to Armenians, erysipelas-like skin lesions are not common in this area, and clinical criteria are the preferred methods in diagnosis of FMF.
机译：背景。家族性地中海热（FMF）是一种周期性的AR自发性疾病。这项全面的研究将伊朗的FMF描述为一个靠近地中海地区的国家。材料和方法。来自国家FMF注册中心的403名患者按照Tel-Hashomer标准进行了研究，其中239名患者进行了MEFV基因突变分析。如有需要，数据将通过SPSS v20.Results进行分析。女性175例（43.4％），男性228例（56.6％）。平均年龄为21.3岁。腹部疼痛的发生率为93.3％，发烧率为88.1％。腹痛是（49.6％）患者的主要主诉。发作之间的平均间隔为36.5±29.6天，每个发作的平均持续时间为43.3±34.5小时。有15.1％的患者有积极的家族史，有12.7％的患者曾经做过手术;在52.3％的患者中，诊断延迟超过三年。分析了12个常见的MEFV基因突变，无突变的占21.33％，具有复合杂合子的占39.7％，有杂合的占25.52％，有纯合的占13.38％。最常见的化合物基因型是M694V-V726A（％10.46），在等位基因中，M694V（％20.9）和V726A（％12.7）分别是最常见的突变。 M694V是最常见的突变，最常见的化合物基因型是M694V-V726A。我们的基因型结果与阿拉伯人相似，在某种程度上与亚美尼亚人相似，丹毒样皮肤病变在该地区并不常见，临床标准是诊断FMF的首选方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号