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Current Concepts in the Management of Rheumatoid Hand

机译:类风湿手管理的最新概念

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Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a T cell-driven autoimmune process, which majorly involves the diarthrodial joints. It affects 1% of the US population, and approximately 70% of patients with RA develop pathologies of the hand, especially of the metacarpophalangeal joints (MCP). Furthermore, also the extensor and flexor tendons of the fingers are frequently involved. The first line of treatment should be conservative. Three general classes of drugs are currently available for RA: nonsteroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying antirheumatic drugs (DMARDs). Encouraging results have been obtained using DMARDs. However, when severe deformities occur or when patients are unresponsive to medical management and injections therapy, surgical intervention should be performed to relieve pain and restore function. Several surgical options have been described for the management of MCP joint deformities, including soft tissue procedures, arthrodesis, and prosthetic replacement. Tendons ruptures are generally managed with tendon transfer surgery, while different surgical procedures are available to treat fingers deformities. The aim of the present review is to report the current knowledge in the management of MCP joint deformities, as well as tendons damage and fingers deformities, in patients with RA.
机译:类风湿关节炎(RA)是一种由T细胞驱动的自身免疫过程引起的慢性炎性疾病,主要涉及穿刺关节。它影响了1%的美国人口,大约70%的RA患者出现了手部病变,尤其是掌指关节(MCP)。此外,还经常涉及手指的伸肌和屈肌腱。一线治疗应保守。目前可用于RA的药物分为三大类:非甾体抗炎药(NSAID),皮质类固醇和抗风湿病药物(DMARD)。使用DMARD获得了令人鼓舞的结果。但是,当发生严重畸形或患者对药物治疗和注射疗法无反应时,应进行手术干预以减轻疼痛并恢复功能。已经描述了几种用于治疗MCP关节畸形的手术方法,包括软组织手术,关节固定术和假体置换。肌腱断裂通常通过肌腱转移手术进行处理,而不同的手术方法可用于治疗手指畸形。本综述的目的是报告在RA患者中MCP关节畸形以及肌腱损伤和手指畸形的管理方面的最新知识。

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