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首页> 外文期刊>International journal of rheumatology >Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012
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Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012

机译：常见病毒病原体与自报告关节炎之间的全人群关联：NHANES 2009-2012

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Objective. Persistent infectious agents have been implicated in chronic and recurrent inflammation, which may trigger or worsen many types of arthritis. Our objective was to determine whether exposure to herpes simplex virus (HSV) and human papillomavirus (HPV) is associated with self-reported arthritis among US adults. Methods. We used data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2009 until 2012 (N of examined adults ages 20-69 = 9483). Participants were classified as having arthritis by self-report. Viral serology for HSV-1 and HSV-2 and HPV PCR studies from oral rinse and vaginal swabs were available for analysis. We compared HSV-1 and HSV-2 seropositivity as well as oral and vaginal HPV DNA positivity between participants with self-reported arthritis vs. those without, adjusting for age, gender, race, income, education, BMI, and the use of immunosuppressive medications. We used three comparator outcomes, gout, kidney stones, and hypertension, to evaluate whether the associations were specific or not to arthritis. Results. Arthritis was associated with older age, female gender, non-Hispanic White and Non-Hispanic Black race, higher BMI, and lower socioeconomic status. HSV-2 seropositivity, but not HSV-1 seropositivity, was independently associated with arthritis after adjustment for age, gender, race, income, education, BMI, and the use of immunosuppressive medications AOR 1.48 (1.10-1.99). Oral HPV DNA positivity was also independently associated with arthritis AOR 1.63 (1.17-2.28). After adjustment, there was no statistically significant difference in vaginal HPV DNA positivity between those with vs. those without arthritis AOR 1.22 (0.90-1.66). There were no significant associations between viral exposures and any of the comparator outcomes. Conclusions. HSV-2 seropositivity and oral HPV DNA positivity were associated with self-reported arthritis and not with comparator outcomes, after adjustment for multiple potential confounders. These findings should be confirmed in longitudinal studies.
机译：目的。持久性传染原与慢性和复发性炎症有关，可能引发或加重许多类型的关节炎。我们的目的是确定暴露于单纯疱疹病毒（HSV）和人乳头瘤病毒（HPV）是否与美国成年人自我报告的关节炎相关。方法。我们使用了从2009年到2012年的两个连续周期的美国国家健康与营养检查调查（NHANES）的数据（受检的20至69岁成年人的N = 9483）。根据自我报告，参与者被分类为患有关节炎。 HSV-1和HSV-2的病毒血清学以及来自口腔冲洗液和阴道拭子的HPV PCR研究可用于分析。我们比较了患有自报告关节炎的参与者与未报告关节炎的参与者之间的HSV-1和HSV-2血清阳性以及口腔和阴道HPV DNA阳性，并调整了年龄，性别，种族，收入，教育程度，BMI和使用免疫抑制剂药物。我们使用了三种比较结果，痛风，肾结石和高血压，以评估相关性是否与关节炎有关。结果。关节炎与年龄，女性，非西班牙裔白人和非西班牙裔黑人种族，较高的BMI和较低的社会经济地位有关。在调整了年龄，性别，种族，收入，教育，BMI和使用免疫抑制药物AOR 1.48（1.10-1.99）之后，HSV-2血清阳性但与HSV-1血清阳性无关，与关节炎独立相关。口服HPV DNA阳性也与关节炎AOR 1.63（1.17-2.28）相关。调整后，有或没有AOR 1.22（0.90-1.66）的人之间的阴道HPV DNA阳性之间没有统计学上的显着差异。病毒暴露与任何比较结果之间均无显着关联。结论。在调整了多个潜在的混杂因素后，HSV-2血清阳性和口服HPV DNA阳性与自我报告的关节炎相关，与比较结果无关。这些发现应在纵向研究中得到证实。

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