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首页> 外文期刊>International journal of rheumatology >The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
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The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis

机译：泼尼松对类风湿关节炎患者结核菌素皮肤试验反应的影响

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Objectives. To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. Method. We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals. Results. Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=−0.293, p=0.186, respectively). Conclusions. Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated.
机译：目标。评估类风湿关节炎（RA）患者中泼尼松和甲氨蝶呤（MTX）的治疗持续时间和剂量与TST反应硬结直径之间的相关性。方法。我们回顾性分析了TNF-i治疗候选RA患者的连续病例。记录TST测量值，泼尼松和甲氨蝶呤的剂量以及治疗时间。从健康受试者中随机选择对照组。我们比较了以下三组目前接受泼尼松治疗的RA患者，未接受泼尼松治疗的RA患者和健康个体之间的TST反应大小。结果。我们的研究样本包括43名接受泼尼松治疗的RA患者，22名泼尼松初治患者和195名健康受试者。两组之间的平均TST无显着差异（分别为5.3±6.6、7.8±6.2和7.6±7.0，p = 0.149）。在有和没有泼尼松治疗的患者中，TST大小与泼尼松uy（r = 0.229，p = 0.140）或甲氨蝶呤uy之间没有相关性（r = 0.219，p = 0.158; r = −0.293，p = 0.186） 。结论。我们的结果表明，泼尼松治疗可能不会影响RA患者中的TST反应大小。另外，RA患者的TST反应可能与健康个体相似。因此，我们建议应重新评估5 mm TST反应的标准，以定义我们人群中潜在的TB感染。

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