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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Evaluation of outcome of pregnancy complicated by intrahepatic cholestasis of pregnancy
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Evaluation of outcome of pregnancy complicated by intrahepatic cholestasis of pregnancy

机译：妊娠结局并发肝内胆汁淤积的评估

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Background: Obstetric cholestasis (OC), also known as intrahepatic cholestasis of pregnancy (ICP), is a hepatic disease unique to pregnancy which presents with intense generalized pruritus without any skin rash. The aim is to study the outcome of pregnancy both maternal and fetal complicated by OC. Methods: This retrospective case control study was conducted at the Department of Obstetrics and Gynecology, Patna Medical College and Hospital, Patna. The medical records of all women with OC who delivered between Jan 2015 and Jan 2016 were reviewed. Results: The incidence of OC was 8.2%. The most common symptom was generalized pruritus which appeared after 28 weeks in 73.3% cases. The cesarean section rate was 93.3%. A higher incidence of meconium staining in amniotic fluid at delivery (17.1% vs 1.1%, p0.005) and preterm premature rupture of membranes (8.9% vs 1.1%, p0.01) was noted without an increase in preterm delivery rate (24.4% vs 15.6%). There was no statistically significant difference in the following parameter - pathological cardiotocography, 1-5 minuteApgar score 7, intrauterine growth restriction, neonatal intensive care admission or perinatal mortality. There was no case of postpartum hemorrhage. Conclusions: The incidence of OC is high in the Indian population. Perinatal outcome is good in actively managed women, although at the cost of a high intervention rate.
机译：背景：产科胆汁淤积症（OC），也称为妊娠肝内胆汁淤积症（ICP），是妊娠所特有的肝病，表现为强烈的全身性瘙痒症，无皮疹。目的是研究母体和胎儿并发OC的妊娠结局。方法：这项回顾性病例对照研究是在巴特那医学院和巴特那医学院妇产科进行的。回顾了2015年1月至2016年1月间分娩的所有OC妇女的病历。结果：OC的发生率为8.2％。最常见的症状是全身性瘙痒症，在73.3％的病例中28周后出现。剖宫产率为93.3％。观察到分娩时羊水中胎粪污染的发生率较高（17.1％vs 1.1％，p <0.005）和胎膜早破（8.9％vs 1.1％，p <0.01），而早产率没有增加（24.4） ％和15.6％）。下列参数无统计学意义上的显着差异：病理心动图，1-5分钟Apgar评分<7，子宫内生长受限，新生儿重症监护或围产期死亡率。没有产后出血的情况。结论：OC的发生率在印度人口中较高。在积极管理的妇女中，围产期结局良好，尽管要付出高干预率。

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