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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >A comparison of cervical cancer screening methods: pap smear, liquid based cytology and VIA VILI
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A comparison of cervical cancer screening methods: pap smear, liquid based cytology and VIA VILI

机译：宫颈癌筛查方法的比较：宫颈涂片检查，液基细胞学检查和VIA VILI

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Background: There are multiple screening methods available for screening cervical cancer with their advantages and disadvantages, researches that compare the sensitivity, specificity, positive and negative predictive values of these tests in a low-cost setting specific to a geographical area is lacking and has to be enhanced. The objective of this study was to determine and compare the agreement, sensitivity, specificity and predictive values of conventional Pap smear cytology, liquid-based cytology and VIA/VILI with cervix biopsy. Methods: This cross sectional study was conducted on women of 35 years of age. Pap smear specimen was collected followed by Liquid Base Cytology (LBC) using cytobrush specimen after which visual inspection with 5% acetic acid (VIA) and visual inspection with Lugol’s Iodine (VILI) procedure was carried out and followed by cervix biopsy. All methods were analyzed for accuracy. Results: Sensitivity was lowest for PAP smear (39.1%, 95% CI 19.18% to 59.1%), followed by VIA VILI (95.7%, 95% CI 87.32% to 100%), and highest for LBC (100.0%). The negative predictive value was lowest for PAP smear (87.4%, 95% CI 81.21% to 93.6%), followed by VIA VILI (99.0%, 95% CI 96.99% to 100.0%) and highest for LBC (100%). The overall diagnostic accuracy was lowest for PAP smear (88.3%) followed by VIA/VILLI (99.2%) and highest for LBC (100%). Conclusions: Treatment decisions based on findings of the PAP smear have to be taken with caution, considering the lower sensitivity. Wherever resources are available more accurate screening methods like liquid-based cytology must be used.
机译：背景：有多种筛查方法可用于筛查宫颈癌的优缺点，目前尚缺乏一项针对在特定地理区域的低成本环境中比较这些检测的敏感性，特异性，阳性和阴性预测值的研究，被增强。这项研究的目的是确定和比较宫颈涂片常规宫颈涂片细胞学，液基细胞学和VIA / VILI的一致性，敏感性，特异性和预测价值。方法：这项横断面研究是针对年龄大于35岁的女性进行的。收集巴氏涂片标本，然后使用细胞刷标本进行液基细胞学检查（LBC），然后进行5％乙酸（VIA）目视检查和Lugol碘（VILI）程序目视检查，然后进行宫颈活检。分析所有方法的准确性。结果：PAP涂片的敏感性最低（39.1％，95％CI 19.18％至59.1％），其次是VIA VILI（95.7％，95％CI 87.32％至100％），LBC最高（100.0％）。 PAP涂片的阴性预测值最低（87.4％，95％CI 81.21％至93.6％），其次是VIA VILI（99.0％，95％CI 96.99％至100.0％），而LBC最高（100％）。 PAP涂片的总体诊断准确度最低（88.3％），其次是VIA / VILLI（99.2％），而LBC最高（100％）。结论：考虑到PAP涂片敏感性较低，必须谨慎做出基于PAP涂片检查结果的治疗决策。只要有资源，就必须使用更准确的筛查方法，例如基于液体的细胞学检查。

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