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首页> 外文期刊>International journal of rheumatology >Anti--enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights
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Anti--enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights

机译：患炎性疾病的小儿血清中的抗烯醇酶抗体：诊断和致病性见解

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Human glycolytic enzyme α-enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti-α-enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the purpose to evaluate it as a novel diagnostic marker. 80 healthy blood donors and 194 paediatric patients affected by Juvenile idiopathic arthritis (JIA), celiac disease (CD), Crohn's Disease (CrD), hereditary periodic fever (HPF), and PFAPA syndrome were included in the study. HPF patients showed high levels of AAE antibodies, whereas JIA, CD, and CrD presented only partial results. Benign fevers such as PFAPA were almost negative for AAE Abs. These findings suggested that the genetic dysfunction of inflammasome associated with HPF could lead to the formation of AAE Abs that could be used for an early and easy diagnosis.
机译：人糖酵解酶α-烯醇酶与人类疾病和炎症有关。为了评估其作为新型诊断标记物的功效，开发了一种ELISA试验来测量血清中的抗α-烯醇酶AAE IgG和AAE IgA。该研究包括80名健康献血者和194名受少年特发性关节炎（JIA），腹腔疾病（CD），克罗恩病（CrD），遗传性周期性发热（HPF）和PFAPA综合征影响的儿科患者。 HPF患者显示出高水平的AAE抗体，而JIA，CD和CrD仅显示部分结果。 PFAPA等良性发热对AAE抗体几乎呈阴性。这些发现表明，与HPF相关的炎性体的遗传功能障碍可能导致AAE Abs的形成，可用于早期和容易的诊断。

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