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首页> 外文期刊>International journal of rheumatology >Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
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Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

机译:凋亡调节作为治疗系统性硬化症的有希望的目标。

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Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets.
机译:弥漫性全身性硬化症(SSc)是一种致命的自身免疫性疾病,其特征是过多的ECM沉积导致皮肤和内部器官功能丧失。凋亡是该疾病所有阶段涉及的关键机制:血管损伤,免疫功能障碍和纤维化。本文的目的是收集与SSc相关的细胞凋亡的新发现,以突出细胞凋亡与纤维化之间的关系,并确定新的治疗靶标。

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