• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Reproductive Medicine >Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome: The Case for Metabolomics Studies
【24h】

Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome: The Case for Metabolomics Studies

机译：追求IVF结果的生物标志物的代谢物谱分析：代谢组学研究的案例

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. This paper presents the literature on biomarkers ofin vitrofertilisation (IVF) outcome, demonstrating the progression of these studies towards metabolite profiling, specifically metabolomics. The need for more, and improved, metabolomics studies in the field of assisted conception is discussed.Methods. Searches were performed on ISI Web of Knowledge SM for literature associated with biomarkers of oocyte and embryo quality, and biomarkers of IVF outcome in embryo culture medium, follicular fluid (FF), and blood plasma in female mammals.Results. Metabolomics in the field of female reproduction is still in its infancy. Metabolomics investigations of embryo culture medium for embryo selection have been the most common, but only within the last five years. Only in 2012 has the first metabolomics investigation of FF for biomarkers of oocyte quality been reported. The only metabolomics studies of human blood plasma in this context have been aimed at identifying women with polycystic ovary syndrome (PCOS).Conclusions. Metabolomics is becoming more established in the field of assisted conception, but the studies performed so far have been preliminary and not all potential applications have yet been explored. With further improved metabolomics studies, the possibility of identifying a method for predicting IVF outcome may become a reality.
机译：背景。本文介绍了体外受精（IVF）结果生物标志物的文献，证明了这些研究朝着代谢物谱，特别是代谢组学发展。讨论了在辅助受孕领域需要进行更多和改进的代谢组学研究的方法。在ISI Web of Knowledge SM上进行了搜索，以寻找与雌性哺乳动物的卵母细胞和胚胎质量的生物标志物以及胚胎培养基，卵泡液（FF）和血浆中IVF结局的生物标志物相关的文献。女性生殖领域的代谢组学仍处于起步阶段。用于胚胎选择的胚胎培养基的代谢组学研究最为普遍，但仅在最近五年内。仅在2012年，才报道了FF对卵母细胞质量生物标志物的首次代谢组学研究。在这种情况下，人类血浆的唯一代谢组学研究旨在鉴定患有多囊卵巢综合征（PCOS）的妇女。代谢组学在辅助受孕领域越来越成熟，但迄今为止进行的研究只是初步的，尚未探索所有潜在的应用。随着代谢组学研究的进一步改进，确定预测IVF结果的方法的可能性可能成为现实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号