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首页> 外文期刊>International Journal of Reproductive Medicine >Natural Killer Cells and Their Activation Status in Normal Pregnancy
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Natural Killer Cells and Their Activation Status in Normal Pregnancy

机译：天然杀伤细胞及其在正常妊娠中的激活状态

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Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11+6–13+6weeks’ gestation, 46 at 20+0–22+4weeks, and 42 at 31+6–33+5weeks. The number of peripheral blood NK cells decreased, whereas the percentage of activated CD69 expressing NK cells increased from the first to the third trimester of pregnancy. This study shows the course of peripheral blood NK cells and activated CD69 expressing NK cells in uncomplicated nulliparous singleton pregnancies. This is a first step in understanding their implication in pathological pregnancies.
机译：外周血激活的NK细胞计数增加与流产和体外受精治疗失败的风险增加有关。然而，尚未描述在正常和病理性妊娠中对植入和早期流产后激活的外周血NK细胞的评估。通过流式细胞术对单胎妊娠健康妇女的CD69表达NK细胞总数进行了测量，包括妊娠11 + 6–13 + 6周时45例，20 + 0–22 + 4周时46例和31 + 6–33 +时42例5周。从妊娠的前三个月到三个月，外周血NK细胞的数量减少，而表达CD69的活化NK细胞的百分比增加。这项研究显示了在无并发症的单胎妊娠中外周血NK细胞和表达CD69的活化NK细胞的过程。这是了解其在病理妊娠中的含义的第一步。

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