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首页> 外文期刊>International Journal of Scientific World >Formulation and evaluation of lecithin organogel for treatment of arthritis
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Formulation and evaluation of lecithin organogel for treatment of arthritis

机译：卵磷脂有机凝胶的配方和治疗关节炎的评估

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Background: Arthritis is a disease of the joint that involves inflammation of one or more joints. Topical administration of NSAIDs could deliver lornoxicam to the site of action in rheumatic diseases, which would reduce the gastrointestinal complications and side effects of the drug. Methods: In this method, the oily phase was prepared by dispersing the specific amount (ratio; 40:60) of purified lecithin at room temperature in isopropyl myristate as dispersing and emulsifying agent. The aqueous phase of polypropylene was prepared by dispersing a weighed amount of polypropylene and glycerol in water. It was stored at 2-4 oC overnight for the effective dissolution. The aqueous phase was slowly added in oily phase with stirring at 400 rpm using a mechanical stirrer. The prepared organogel of lornoxicam were evaluated for its appearance, organoleptic characteristic, viscosity, gelation temperature, drug content and in vitro release study. In vivo evaluation for analgesic activity of formulation was carried out in terms of skin irritation study, hot plate method; writhing test and edema paw induce method. Results: The drug content of organogel formulations was found in the range of 92.43±2.10-97.93±0.31% indicating uniform distribution of drug through the base and no interaction of drug with component of base. Posthoc Dunnet’s t-test by employing statistical software, GraphPad InStat 3. It’s shown differences between groups were considered significant at P < 0.05. Conclusion: The transdermal organogel formulation of lornoxicam could provide significant anti-inflammatory and antirheumatic activity when applied topically and was observed to be functional for topical delivery of lornoxicam.
机译：背景：关节炎是一种关节疾病，涉及一个或多个关节的炎症。 NSAIDs的局部给药可将氯诺昔康递送至风湿性疾病的作用部位，这将减少胃肠道并发症和药物的副作用。方法：在该方法中，通过在室温下将特定量（比例为40:60）的纯化卵磷脂分散在肉豆蔻酸异丙酯中作为分散和乳化剂来制备油相。通过将一定量的聚丙烯和甘油分散在水中来制备聚丙烯的水相。将其在2-4 oC下保存过夜以有效溶解。使用机械搅拌器在400rpm下搅拌的同时将水相缓慢地添加至油相中。对所制备的氯诺昔康有机凝胶的外观，感官特性，粘度，胶凝温度，药物含量和体外释放研究进行了评估。根据皮肤刺激性研究，热板法对制剂的镇痛活性进行了体内评价。扭体试验和水肿爪诱发方法。结果：有机凝胶制剂的药物含量在92.43±2.10-97.93±0.31％的范围内，表明药物在碱中的分布均匀，而药物与碱的成分之间没有相互作用。通过使用统计软件GraphPad InStat 3进行Posthoc Dunnet的t检验。结果表明，各组之间的差异在P <0.05时被认为是显着的。结论：氯诺昔康的透皮有机凝胶制剂在局部应用时可提供显着的抗炎和抗风湿活性，并被观察到可用于氯诺昔康的局部递送。

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