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首页> 外文期刊>International Journal of Nanomedicine >Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits
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Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

机译：纳米管阳极氧化钛植入物的庆大霉素涂层减少了与植入物有关的骨髓炎并增强了兔的骨生物相容性

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Titanium and titanium alloy are widely used as orthopedic implants for their favorable mechanical properties and satisfactory biocompatibility. The aim of the present study was to investigate the antibacterial effect and bone cell biocompatibility of a novel implant made with nanotubular anodized titanium coated with gentamicin (NTATi-G) through in vivo study in -rabbits. The animals were divided into four groups, each receiving different kinds of implants, that is, NTATi-G, titanium coated with gentamicin (Ti-G), nanotubular anodized titanium uncoated with gentamicin (NTATi) and titanium uncoated with gentamicin (Ti). The results showed that NTATi-G implant prevented implant-related osteomyelitis and enhanced bone biocompatibility in vivo. Moreover, the body temperature of rabbits in NTATi-G and Ti-G groups was lower than those in Ti groups, while the weight of rabbits in NTATi-G and Ti-G groups was heavier than those in NTATi and Ti groups, respectively. White blood cell counts in NTATi-G group were lower than NTATi and Ti groups. Features of myelitis were observed by X-ray films in the NTATi and Ti groups, but not in the NTATi-G and Ti-G groups. The radiographic scores, which assessed pathology and histopathology in bone tissues, were significantly lower in the NTATi-G and Ti-G groups than those in the NTATi and Ti groups, respectively ( P <0.05). Meanwhile, explants and bone tissue culture demonstrated significantly less bacterial growth in the NTATi-G and Ti-G groups than in the NTATi and Ti groups, respectively ( P <0.01). The bone volume in NTATi-G group was greater than Ti-G group, and little bone formation was seen in NTATi and Ti groups.
机译：钛和钛合金由于其良好的机械性能和令人满意的生物相容性而被广泛用作整形外科植入物。本研究的目的是通过在兔子体内进行研究，以研究用纳米管阳极化钛包覆庆大霉素（NTATi-G）制成的新型植入物的抗菌作用和骨细胞生物相容性。将动物分为四组，每组接受不同种类的植入物，即NTATi-G，涂有庆大霉素（Ti-G）的钛，未涂有庆大霉素（NTATi）的纳米管阳极氧化钛和未涂有庆大霉素（Ti）的钛。结果表明，NTATi-G植入物可预防植入物相关的骨髓炎并增强体内的骨生物相容性。而且，NTATi-G和Ti-G组的兔的体温低于Ti组，而NTATi-G和Ti-G组的兔的体重分别比NTATi和Ti组的重。 NTATi-G组的白细胞计数低于NTATi和Ti组。 X线摄片在NTATi和Ti组中观察到脊髓炎的特征，而在NTATi-G和Ti-G组中则没有观察到。 NTATi-G组和Ti-G组的放射线评分显着低于骨AAT组和Ti组（P <0.05），该放射线评分评估了骨组织的病理和组织病理学（P <0.05）。同时，在NTATi-G和Ti-G组中，外植体和骨组织培养物的细菌生长明显少于NTATi和Ti组（P <0.01）。 NTATi-G组的骨量大于Ti-G组，而NTATi和Ti组的骨形成很少。

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