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首页> 外文期刊>International Journal of Nanomedicine >Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: evaluation of size-dependent imaging properties, storage stability and safety
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Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: evaluation of size-dependent imaging properties, storage stability and safety

机译：葡聚糖包被的超顺磁性氧化铁纳米粒子用于磁共振成像：评估尺寸依赖的成像特性，存储稳定性和安全性

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Background: Rising criticism of currently available contrast agents for magnetic resonance imaging, either due to their side effects or limited possibilities in terms of functional imaging, evoked the need for safer and more versatile agents. We previously demonstrated the suitability of novel dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) for biomedical applications in terms of safety and biocompatibility. Methods: In the present study, we investigated the size-dependent cross-linking process of these particles as well as the size dependency of their imaging properties. For the latter purpose, we adopted a simple and easy-to-perform experiment to estimate the relaxivity of the particles. Furthermore, we performed an extensive analysis of the particles’ storage stability under different temperature conditions, showing their superb stability and the lack of any signs of agglomeration or sedimentation during a 12 week period. Results: Independent of their size, SPIONDex displayed no irritation potential in a chick chorioallantoic membrane assay. Cell uptake studies of ultra-small (30?nm) SPIONDex confirmed their internalization by macrophages, but not by non-phagocytic cells. Additionally, complement activation-related pseudoallergy (CARPA) experiments in pigs treated with ultra-small SPIONDex indicated the absence of hypersensitivity reactions. Conclusion: These results emphasize the exceptional safety of SPIONDex, setting them apart from the existing SPION-based contrast agents and making them a very promising candidate for further clinical development.
机译：背景：由于其副作用或在功能成像方面的可能性有限，对目前可用的磁共​​振成像造影剂的批评日益强烈，这引发了对更安全，用途更广泛的造影剂的需求。我们先前在安全性和生物相容性方面证明了新型葡聚糖包被的超顺磁性氧化铁纳米粒子（SPION Dex ）在生物医学中的适用性。方法：在本研究中，我们研究了这些颗粒的尺寸依赖性交联过程以及其成像性质的尺寸依赖性。为此，我们采用了一个简单易行的实验来估算颗粒的弛豫性。此外，我们对颗粒在不同温度条件下的储存稳定性进行了广泛的分析，显示了其出色的稳定性以及在12周内没有任何团聚或沉淀的迹象。结果：SPION Dex 大小不一，在鸡绒膜尿囊膜测定中未显示刺激性。超小型（30？nm）SPION Dex 的细胞摄取研究证实了它们被巨噬细胞内在化，但未被非吞噬细胞内化。此外，在超小型SPION Dex 处理的猪中，补体激活相关的拟变态反应（CARPA）实验表明没有超敏反应。结论：这些结果强调了SPION Dex 的卓越安全性，使其与现有的基于SPION的造影剂区分开来，使其成为进一步临床开发的极有希望的候选者。

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