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首页> 外文期刊>International Journal of Nanomedicine >New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
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New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell

机译：以N-戊二酰磷脂酰乙醇胺为外壳的新型表面改性固体脂质纳米颗粒

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Background: Solid lipid nanoparticles (SLNs) are colloidal carrier systems which provide controlled-release profiles for many substances. In this study, we prepared aqueous dispersions of lipid nanoparticles using a modified, pH-sensitive derivative of phosphatidylethanolamine. Methods: SLNs were prepared using polysorbate 80 as the surfactant and tripalmitin glyceride and N-glutaryl phosphatidylethanolamine as the lipid components. Particle size, polydispersity index, and zeta potential were examined by photon correlation spectroscopy. Morphological evaluation was performed using scanning electron microscopy, atomic force microscopy, and differential scanning calorimetry. Results: Photon correlation spectroscopy revealed a particle hydrodynamic diameter of 165.8 nm and zeta potential of –41.6.0 mV for the drug-loaded nanoparticles. Atomic force microscopy investigation showed the nanoparticles to be 50–600 nm in length and 66.5 nm in height. Differential scanning calorimetry indicated that the majority of SLNs possessed less ordered arrangements of crystals compared with corresponding bulk lipids, which is favorable for improving drug-loading capacity. Drug-loading capacity and drug entrapment efficiency values for the SLNs were 25.32% and 94.32%, respectively. Conclusion: The SLNs prepared in this study were able to control the release of triamcinolone acetonide under acidic conditions.
机译：背景：固体脂质纳米颗粒（SLN）是胶体载体系统，可为许多物质提供控释特性。在这项研究中，我们使用磷脂酰乙醇胺的改性，对pH敏感的衍生物制备了脂质纳米颗粒的水分散体。方法：以聚山梨酯80为表面活性剂，三棕榈酸甘油酯和N-戊二酰磷脂酰乙醇胺为脂质成分制备SLN。通过光子相关光谱法检查粒度，多分散指数和ζ电势。使用扫描电子显微镜，原子力显微镜和差示扫描量热法进行形态学评估。结果：光子相关光谱显示载药纳米粒子的粒子流体动力学直径为165.8 nm，ζ电势为–41.6.0 mV。原子力显微镜研究显示，纳米粒子的长度为50-600 nm，高度为66.5 nm。差示扫描量热法表明，大多数SLN与相应的体脂相比，其晶体排列顺序较不规则，这有利于提高载药量。 SLNs的载药量和截留效率分别为25.32％和94.32％。结论：本研究制备的SLNs能够在酸性条件下控制曲安奈德的释放。

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