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In Silico DNA computing

机译:在Silico DNA计算中

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摘要

DNA computing, one of the constituents of nature-inspired computing has two forms, namely, in vitro DNA computing and in silico DNA computing. In vitro DNA computing is the most popular one, where the authors deal with the topology of a dynamic structure consists of macromolecules (e.g., DNA) to solve computational problems. It started with the work of Adleman where in vitro DNA strands were synthesized to solve the travelling salesman problem [5]. Ullah et al. [4] have given an account of the usages of in vitro DNA computing. On the other hand, in silico DNA computing, the other form of DNA computing takes inspirations from the central dogma of molecular biology [6] and performs computation in silicon-based computing machines (ie., in ordinary computers) to solve computational problems. The central dogma of molecular biology means “once (sequential) information has passed into protein it cannot get out again” [6]. In other words, mappings of DNA/RNA to DNA/RNA/protein are possible but not protein to DNA/RNA/protein [3,4].
机译:DNA计算是受自然启发的计算的组成部分之一,具有两种形式,即体外DNA计算和计算机模拟DNA计算。体外DNA计算是最流行的一种方法,其中作者处理由大分子(例如DNA)组成的动态结构的拓扑来解决计算问题。它始于Adleman的工作,其中合成了体外DNA链以解决旅行推销员问题[5]。 Ullah等。 [4]给出了体外DNA计算的用途。另一方面,在计算机DNA计算中,DNA计算的另一种形式是从分子生物学的中心教条中获得启发[6],并在基于硅的计算机中(即,在普通计算机中)执行计算以解决计算问题。分子生物学的中心教条意味着“一旦(顺序)信息传递到蛋白质中,它就无法再次释放” [6]。换句话说,可以将DNA / RNA映射到DNA / RNA /蛋白质,但不能将蛋白质映射到DNA / RNA /蛋白质[3,4]。

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