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首页> 外文期刊>International Journal of Soil, Sediment and Water >Effects of Soil Matrix and Aging on the Dermal Bioavailability of Polycyclic Aromatic Hydrocarbons in the Soil
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Effects of Soil Matrix and Aging on the Dermal Bioavailability of Polycyclic Aromatic Hydrocarbons in the Soil

机译：土壤基质和老化对土壤中多环芳烃皮肤生物利用度的影响

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The potential health risk from exposure to chemically contaminated soil can be assessed from bioavailability studies. The aims of this research were: (a) to determine the dermal bioavailability of contaminants in soil for representatives of the polycyclic aromatic hydrocarbon class of chemicals, namely, benzo(a)pyrene and naphthalene, and (b) to examine the relative contribution of soil matrix and chemical sequestration in soil with time (“aging”) on their bioavailability. In vitro flow-through diffusion cell studies were performed utilizing dermatomed male pig skin and radioactive chemicals to measure dermal penetration. Volatilization of naphthalene was predominant in reducing the amount of chemical available for dermal penetration. Immediate contact with either of two soils reduced volatilization, however, only the soil with higher clay content resulted in reduced penetration. Aging in higher sand content soil and higher clay content soil further reduced skin penetration by 23 and 70 fold, respectively, versus naphthalene in the absence of soil. Benzo(a)pyrene penetration was reduced >88% following immediate contact with either soil with further reductions occurring after aging. While aging in either soil reduced the dermal penetration of both naphthalene and benzo(a)pyrene, the effect on naphthalene was much greater. The results of this study suggest that the bioavailability from dermal exposure to the polycyclic aromatic chemicals examined can be significantly reduced by soil matrix and aging in soil, resulting in reduced potential health risk following dermal exposure.
机译：可以从生物利用度研究中评估因接触化学污染土壤而引起的潜在健康风险。这项研究的目的是：（a）确定土壤中污染物的皮肤生物利用度，以代表多环芳烃类化学品即苯并（a）and和萘;以及（b）检查土壤基质和化学螯合剂随时间（“老化”）对其生物利用度的影响。体外穿流扩散细胞研究是使用经过皮切开的雄性猪皮肤和放射性化学物质测量皮肤穿透力而进行的。萘的挥发主要是减少可用于皮肤渗透的化学物质的量。立即与两种土壤中的任何一种接触都会减少挥发，但是，只有粘土含量较高的土壤才会导致渗透性降低。与不含土壤的萘相比，在含沙量较高的土壤和含粘土量较高的土壤中的老化分别使皮肤渗透率分别降低了23倍和70倍。立即与任一种土壤接触后，苯并（a）penetration的渗透率降低> 88％，老化后进一步降低。虽然在任何一种土壤中老化都会降低萘和苯并（a）both的皮肤渗透率，但对萘的影响要大得多。这项研究的结果表明，土壤基质和土壤老化会显着降低从皮肤接触多环芳族化学品引起的生物利用度，从而降低皮肤接触后潜在的健康风险。

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