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首页> 外文期刊>International Journal of Soil, Sediment and Water >Determination of Oral or Dermal Benzene Exposure from Contaminated Soils
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Determination of Oral or Dermal Benzene Exposure from Contaminated Soils

机译：污染土壤中口服或皮肤接触苯的测定

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Soil contamination with dangerous, toxic chemicals remains one of the most difficult problems in this era. Health risk assessments often do not consider the amount of chemicals in soil that are absorbed and their disposition (kinetics). The aim of these studies was to compare the extent to which adsorption to either a sand or clay content soil affects the kinetics and manner which benzene is subsequently handled in orally or dermally exposed rats. Dermal exposure increased absorption half-lives (t1/2) by 25, 60 and 44-fold compared with oral exposure to benzene alone, or in the presence of sandy or clay soil, respectively. The elimination t1/2 following dermal versus oral exposure were increased about 2-fold in benzene alone and sandy soil groups, while in the clay soil group the increase was 13-fold. The area under the blood concentration versus time curve (AUC) of benzene in the presence of either soil was increased after oral and decreased after dermal exposure compared with exposure to benzene alone. The urinary recovery, 48 hours following dermal exposure to benzene alone, was 3-fold greater than following oral exposure. Tissue distribution after all oral exposures resulted in the highest concentrations of radioactivity in gastric contents > stomach > fat > duodenum > adrenal. The highest tissue concentrations of radioactivity after dermal exposure to benzene alone were kidney > liver > treated skin; however, after exposure in the presence of either soil the highest tissue concentrations were treated skin > kidney > liver. The results of these studies reveal that the presence of sand or clay content soil produced qualitative and quantitative differences in the disposition of benzene in the body following oral or dermal exposures. These differences will impact the risk assessment of benzene.
机译：危险，有毒化学物质对土壤的污染仍然是这个时代最困难的问题之一。健康风险评估通常不考虑土壤中被吸收的化学物质的数量及其处置方式（动力学）。这些研究的目的是比较吸附到沙子或粘土含量土壤上的吸附程度对随后在口腔或皮肤接触的大鼠中处理苯的动力学和方式的影响。与单独口服苯或在沙土或黏土中口服相比，皮肤接触使吸收半衰期（t1 / 2）分别提高了25、60和44倍。真皮和口服接触后，皮肤接触和口腔接触后的消除t1 / 2增加约2倍，而单独的苯和沙土组增加了13倍。与仅暴露于苯相比，在存在任何一种土壤的情况下，口服后苯的血液浓度-时间曲线下面积（AUC）均增加，而皮肤暴露后苯的浓度降低。皮肤单独接触苯后48小时的泌尿恢复率比口服接触后高3倍。所有口腔暴露后的组织分布导致胃内容物>胃>脂肪>十二指肠>肾上腺中的放射性最高浓度。皮肤仅接触苯后，放射性最高组织浓度为肾脏>肝脏>处理过的皮肤。但是，在任何一种土壤中均暴露后，最高组织浓度为皮肤>肾脏>肝脏。这些研究的结果表明，在口腔或皮肤接触后，沙子或粘土含量高的土壤的存在会导致苯在体内的分布产生质和量的差异。这些差异将影响苯的风险评估。

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