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首页> 外文期刊>International Journal of Pharmacy and Pharmaceutical Sciences >STUDY OF THE INCLUSION BEHAVIOUR OF Β-CYCLODEXTRIN WITH ZIPRASIDONE AND ITS PHARMACEUTICAL APPLICATION
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STUDY OF THE INCLUSION BEHAVIOUR OF Β-CYCLODEXTRIN WITH ZIPRASIDONE AND ITS PHARMACEUTICAL APPLICATION

机译：β-环糊精与ZIPRASIDONE的包合行为及其药物应用研究

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摘要

The inclusion complex of the slight water solubility ziprasidone (ZIP) with β-cyclodextrin (β-CD) was investigated by spectrofluorimetry. Influence of pH and β-CD concentration on the fluorescence spectra was reported. The obtained results exhibited that the ZIP was encapsulated in β-CD cavity to form a 1:1 stoichiometry host-guest complex. The inclusion constant was confirmed by Benesi-Hildebrand method. The inclusion complex formation was also confirmed by scanning electron microscopy SEM. Based on the remarkable enhancement of the fluorescence intensity of ZIP in the presence of β-CD a new spectrofluorimetric method for the determination of ZIP was developed. In order to obtain the maximum fluorescence several experimental conditions were optimized. The linear range was 0.5-100 ng mL -1 and correlation coefficient was 0.9992. The detection limit was 0.2 ng mL -1 . The proposed method was successfully applied to the analysis of ZIP in pure and pharmaceutical dosage forms with the satisfactory results. Keywords: Ziprasidone, β-cyclodextrin, Inclusion complex, Spectrofluorimetry.
机译：用分光荧光法研究了微水溶性齐拉西酮（ZIP）与β-环糊精（β-CD）的包合物。报道了pH和β-CD浓度对荧光光谱的影响。获得的结果表明，ZIP被封装在β-CD腔中，形成了1：1的化学计量主客复合体。夹杂常数通过Benesi-Hildebrand法确认。还通过扫描电子显微镜SEM确认了包合物的形成。基于在β-CD存在下ZIP荧光强度的显着提高，开发了一种测定ZIP的新的荧光光谱法。为了获得最大荧光，优化了几个实验条件。线性范围为0.5-100 ng mL -1，相关系数为0.9992。检出限为0.2 ng mL -1。所提出的方法已成功应用于纯净和药物剂型中ZIP的分析，结果令人满意。关键字：齐帕西酮，β-环糊精，包合物，荧光光谱法。

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