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首页> 外文期刊>International Neurourology Journal >Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function
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Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function

机译:关于神经发生在阿尔茨海默病,帕金森氏病和缺血性中风治疗策略中的作用的最新见解;考虑神经元排空功能

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摘要

Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subventricular and subgranular zones have the ability to proliferate and differentiate in order to replace lost or damaged neural cells. There have been many limitations in the clinical application of both endogenous and exogenous neurogenesis for neurological disorders. However, many studies have investigated novel mechanisms in neurogenesis and have shown that these limitations can potentially be overcome with appropriate stimulation and various approaches. We will review concepts related to possible therapeutic strategies focused on the perspective of neurogenesis for the treatment of patients diagnosed with Alzheimer disease, Parkinson disease, and ischemic stroke based on current reports.
机译:诸如阿尔茨海默氏症,帕金森氏症和缺血性中风之类的神经系统疾病的发病率有所增加,并已成为世界范围内重要的健康问题。在这些主要神经系统疾病发生后,目前尚无有效的治疗策略可解决神经系统缺陷。近年来,已被接受的是位于脑室下和颗粒下区域的成年神经干细胞具有增殖和分化的能力,以替代丢失或受损的神经细胞。在神经系统疾病的内源性和外源性神经发生的临床应用中存在许多限制。但是,许多研究已经研究了神经发生中的新机制,并表明通过适当的刺激和各种方法可以克服这些局限性。我们将根据最新报告,回顾与可能的治疗策略相关的概念,这些概念着重于以神经发生的角度治疗被诊断为阿尔茨海默氏病,帕金森氏病和缺血性中风的患者。

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