Objective: To study the gastric anti-secretory and cytoprotective action of ethanolic extract of leaves of Andrographys paniculata . Methods : Effect of ethanolic extract of leaves of A. paniculata gastro-antisecretory and cytoprotective activity was studied in vivo by using gastric wall mucus determination, hypothermic restraint stress-induced ulcers, idomethacin-induced gastric ulcers, reserpine-induced gastric ulcers and necrotizing agent-induced gastric ulcers (cytoprotection studies) methods. Results : Ethanolic extract of leaves of A. paniculata produced a significant decrease in gastric secretion in pylorous ligated rats and a highly significant cytoprotective effect against 80% ethanol-0.6 M HCl, 0.2 M NaOH, and 25% NaCl-induced cytodestruction. Conclusion : Pretreatment with the extract significantly prevented hypothermic stress-induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action A. paniculata can be responsible for its antiulcer activity. Keywords: A. paniculata , Gastric secretion, Gastric ulcers , Cytoprotection, Gastric wall mucus.
展开▼
机译：目的：研究穿心莲叶乙醇提取物对胃的分泌和细胞保护作用。方法：采用胃壁粘液测定，低温束缚应激诱导的溃疡，依多美辛诱导的胃溃疡，利血平诱导的胃溃疡和坏死剂，研究了人参乙醇提取物的抗胃分泌作用和细胞保护活性。 -诱导的胃溃疡（细胞保护研究）的方法。结果：沙棘叶的乙醇提取物在幽门结扎的大鼠中胃分泌显着减少，并且对80％乙醇-0.6 M HCl，0.2 M NaOH和25％NaCl诱导的细胞破坏具有非常显着的细胞保护作用。结论：提取物的预处理可显着预防体温过低引起的胃壁粘液消耗。这些发现表明，显着的抗分泌和细胞保护作用可能对它的抗溃疡活性负责。关键词：沙棘，胃分泌物，胃溃疡，细胞保护，胃壁粘液。
展开▼
