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首页> 外文期刊>Intestinal research. >Inflammatory Bowel Disease-related Colorectal Cancer in the Asia-Pacific Region: Past, Present, and Future
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Inflammatory Bowel Disease-related Colorectal Cancer in the Asia-Pacific Region: Past, Present, and Future

机译：亚太地区与炎症性肠病相关的大肠癌的过去，现在和未来

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Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and key contributing factors include chronic colonic inflammation and the extent and duration of disease. This increase in risk is more likely to result from chronic inflammation of the colonic mucosa than from any clearly defined genetic predisposition. However, globally, the true magnitude of this risk is debatable, since results from different studies are heterogeneous in terms of geographical and methodological variables. The prevalence of IBD-related CRC in the Asia-Pacific region ranges from 0.3% to 1.8% and a recent study found that the cumulative incidence of IBD-related CRC is comparable to that in Western countries. However, the CRC mortality rate in the Asia-Pacific region is on the rise compared with that in Western countries, and a few Asian countries show particularly rapid upward trends in CRC incidence. Although our understanding of the molecular and clinical basis for IBD-related CRC has improved substantially, our means of prevention, endoscopic surveillance, chemoprevention, and prophylactic surgery remain modest at best. Furthermore, published data on IBD-related CRC in the Asia-Pacific region is lacking, and this review addresses many aspects including epidemiology, natural history, etiopathogenesis, morphology, and biological behaviors of IBD-related CRC and sporadic CRC in the Asia-Pacific region. In this review, we will also discuss the risk factors for CRC in IBD patients, endoscopic technology screening, and surveillance programs and management strategies for IBD-related CRC.
机译：炎症性肠病（IBD）患者罹患大肠癌（CRC）的风险增加，关键因素包括慢性结肠炎以及疾病的程度和持续时间。与任何明确定义的遗传易感性相比，这种风险增加更可能是由结肠粘膜的慢性炎症引起的。但是，在全球范围内，这种风险的真实程度值得商,，因为不同研究的结果在地理和方法学变量方面是异质的。亚太地区与IBD相关的CRC患病率介于0.3％至1.8％之间，最近的一项研究发现，与IBD相关的CRC的累积发病率与西方国家相当。但是，与西方国家相比，亚太地区的CRC死亡率呈上升趋势，一些亚洲国家的CRC发病率呈特别迅速的上升趋势。尽管我们对IBD相关CRC的分子和临床基础的了解已大大改善，但我们的预防，内窥镜监测，化学预防和预防性手术的方法充其量仍然充裕。此外，缺乏有关亚太地区与IBD相关的CRC的公开数据，该综述涉及许多方面，包括亚太地区与IBD相关的CRC和散发性CRC的流行病学，自然史，病因，形态和生物学行为。地区。在这篇综述中，我们还将讨论IBD患者CRC的危险因素，内窥镜技术筛查以及IBD相关CRC的监测程序和管理策略。

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