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首页> 外文期刊>International Journal of Surgical Oncology >Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review
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Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review

机译:BRCA1和BRCA2突变携带者的临床考虑:综述。

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Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) andBRCA2genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention.
机译:携带乳腺癌1(BRCA1)和BRCA2基因的遗传突变的个体在其一生中都有罹患乳腺癌和卵巢癌的重大风险。结果,临床医生在突变携带者的咨询,随访和管理中需要考虑重要的考虑因素。这篇综述概述了对罹患乳腺癌和卵巢癌高风险患者的治疗方法的重要方面,包括基因检测标准,筛查指南,手术预防和化学预防。

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