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首页> 外文期刊>International Journal of Surgical Oncology >Mammary Ductal Carcinoma In Situ: A Fresh Look at Architectural Patterns
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Mammary Ductal Carcinoma In Situ: A Fresh Look at Architectural Patterns

机译：乳腺导管原位癌：重新审视建筑模式

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摘要

Mammary ductal carcinoma in-situ (DCIS), a malignant appearing lesion on cytological and histological grounds, is in fact a non-obligate precancer. DCIS is difficult to manage and is sometimes treated more aggressively than invasive carcinoma. Although most DCIS classifications take into account the architectural growth pattern, when it comes to architecture, the literature is full of contradictory information. We examined 289 breast cancers and found DCIS in 265 of the cases. The majority of the DCIS cases were seen in the setting of invasive cancer and only 9% of the cases represented pure DCIS with no invasive cancer. The DCIS commonly displayed a mixed pattern with micropapillary, cribriform and solid components with the micropapillary type being the rarest, occurring seldom on its own. A continuum of growth with a micropapillary pattern evolving into a cribriform type could be seen in some of the cases. This may explain some of the conflicting information, in the literature, regarding the different architectural types of DCIS. The comedo-pattern of necrosis could be seen in all types of DCIS. We therefore conclude that the study of the determinants of growth pattern in DCIS would be the key to unravelling the diverse, often non-concordant evidence one encounters in the literature.
机译：乳腺导管原位癌（DCIS）是一种以细胞学和组织学为基础的恶性病变，实际上是一种非专一性的癌前病变。 DCIS难以管理，有时比浸润性癌更积极地治疗。尽管大多数DCIS分类都考虑了建筑的增长模式，但是当涉及到建筑时，文献中充满了矛盾的信息。我们检查了289例乳腺癌，并在265例病例中发现了DCIS。 DCIS的大多数病例都在浸润性癌的背景下发生，只有9％的病例代表了纯DCIS而无浸润性癌。 DCIS通常表现出由微乳头，筛状和固体成分组成的混合模式，其中微乳头类型最为罕见，很少单独发生。在某些情况下，可以看到具有微乳头状图案的连续生长演变成筛状。这可能解释了文献中有关DCIS的不同体系结构类型的一些相互矛盾的信息。在所有类型的DCIS中都可以看到坏死的粉刺模式。因此，我们得出结论，对DCIS增长模式的决定因素进行研究，将是弄清文献中所遇到的多样且往往不一致的证据的关键。

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