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首页> 外文期刊>International Journal of Surgical Oncology >Is There a Role for Postmastectomy Radiation Therapy in Ductal CarcinomaIn Situ?
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Is There a Role for Postmastectomy Radiation Therapy in Ductal CarcinomaIn Situ?

机译：乳腺切除术在原位导管癌中的放射治疗有作用吗？

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Background. DCIS treated by mastectomy ensures high local control rates. There is limited data on risk for relapse and lack of clear indication for adjuvant radiation therapy (RT). We report a retrospective review on a population of DCIS patients treated with mastectomy. The objective was to identify the overall incidence of relapse, risk factors for local recurrence, and accordingly for whom adjuvant postmastectomy RT may be considered.Methods. This is an IRB-approved retrospective study on a prospective breast cancer database. From 1997 to 2007, we identified 969 patients with diagnoses of DCIS, among them 211 breasts in 207 patients were treated with mastectomy and comprise the study group.Results. With a median followup of 55 months (4.6 years) the 10-year relapse-free survival is 97%. Two of 211 breasts (0.9%) treated with mastectomy developed a local-regional recurrence. Both the relapses were among patients defined as having <1 mm final mastectomy margin.Conclusions. The rare local relapse after mastectomy limits our ability to reliably identify risk factors for relapse. The consideration for postmastectomy RT should be based on an individualized risk evaluating surgical technique used, presence of BRCA mutation, grade and extent of tumor, and proximity of lesion to the margin of resection.
机译：背景。乳房切除术治疗的DCIS可确保较高的局部控制率。关于复发风险的数据有限，且缺乏明确的辅助放射治疗（RT）指征。我们报告回顾性回顾了接受乳腺切除术治疗的DCIS患者人群。目的是确定复发的总体发生率，局部复发的危险因素以及相应的考虑考虑行辅助乳房切除术后放疗的患者。这是一项IRB批准的有关前瞻性乳腺癌数据库的回顾性研究。从1997年至2007年，我们确定了969例诊断为DCIS的患者，其中207例患者中的211例乳房接受了乳房切除术治疗，这是研究组。平均随访55个月（4。6年），其10年无复发生存率为97％。乳房切除术治疗的211个乳房中有2个（0.9％）发生了局部区域复发。两次复发均被定义为最终乳房切除术边缘小于1mm的患者。乳房切除术后罕见的局部复发限制了我们可靠地确定复发危险因素的能力。乳房切除术后放疗的考虑应基于评估手术技术的个体化风险，BRCA突变的存在，肿瘤的等级和程度以及病变与切除边缘的接近程度。

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