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首页> 外文期刊>Iranian journal of public health. >Efficacy and Safety of Dimeticone in the Treatment of Lice Infestation through Prophylaxis of Classmates
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Efficacy and Safety of Dimeticone in the Treatment of Lice Infestation through Prophylaxis of Classmates

机译：狄美替尼预防同学对虱子侵袭的疗效和安全性

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BackgroundWe conducted a study to evaluate efficacy and safety of dimeticone 4%, a lotion with no conventional insecticide activity, to cure lice infection and to prevent spread of infestation/reinfestation by prophylaxis of classmates.Methods:The study is carried out between April 2008 and June 2008 in Petranova International Institute in Rome. A total of 131 children, aged 3 to 13 years (median age: 7 years) were included in the study. All participants received treatment with dimeticone 4% that was applied both to children with the infestation, to cure it, and to all classmates, to prevent the spreading of the infestation. They have been controlled after 7 and 30 days from the application of dimeticone.Results:At baseline we found a positivity of lice infestation in 23/131 children (17.6%), whereas 108/131 (82.4%) children were free from lice. After 7 days of treatment with dimeticone 4%, 7/23 (30.4%) positive children still had lice infestation, with a cure rate of 69.6% (16/23). At 30 days 26/131 children (19.9%) were infested: 15 children were lice free at baseline whereas 11 had lice at both evaluations; the cure rate amounted to 52.2% (12/23). The reinfestation rate (percentage of positive children that showed negativity at baseline) was 5.3% (7/131) at 7 days and 11.5% (15/131) at 30 days.Conclusion:The lower reinfestation rate showed in our trial suggests that this approach could be effective in reducing spreading of head lice in small communities. More studies are needed to confirm our findings.
机译：背景：我们进行了一项研究，以评估4％的Dimeticone（一种没有常规杀虫剂活性的乳液）的疗效和安全性，通过预防同班同学来预防虱子感染和预防侵染/再侵染的传播。方法：该研究于2008年4月至2008年4月之间进行。 2008年6月在罗马Petranova国际学院。该研究共纳入131名3至13岁（中位年龄：7岁）的儿童。所有参加者均接受了4％的双甲硅油治疗，该药物既可用于患病的儿童，也可用于治愈，也适用于所有同学，以防止患病扩散。结果：在基线时，我们发现23/131名儿童（17.6％）的虱子感染为阳性，而108/131名儿童（82.4％）没有虱子。在用4％的替米松酮治疗7天后，仍有7/23（30.4％）阳性儿童发生虱子感染，治愈率为69.6％（16/23）。在第30天，有26/131名儿童（19.9％）被感染：基线时有15名儿童没有虱子，而两次评估中有11名儿童有虱子。治愈率达到52.2％（12/23）。再感染率（基线时呈阴性的阳性儿童百分比）在7天时为5.3％（7/131），在30天时为11.5％（15/131）。结论：本研究显示较低的再感染率表明这种方法可能有效地减少了头虱在小社区中的扩散。需要更多的研究来证实我们的发现。

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