...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian journal of public health. >Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies
【24h】

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

机译：大肠癌患者的组织和血清微量元素浓度：病例对照研究的系统评价

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Trace elements play a pivotal role in Colorectal Cancer (CRC) inhibition and development process. This systematic review provides the basic comparison of case-control studies focusing on concentration of trace elements between those with CRC and controls Methods: The systematic review searched through two databases of Medline and Cochrane up to 24th June 2017. The search strategy focused on Population, Intervention, Comparison, and Outcomes (PICO). We searched the role of trace elements in cancer and focusing on case-control studies in CRC to obtain an insight into the differences in trace element concentrations between those with and without cancer. Results: The serum concentrations of Ca, Cu, Mg, Mn, Se, Si, and Zn were lower in CRC patients but for Co and S the levels were higher in CRC patients. The concentrations of Cd, Cr, Cu, Mg, Mn, Pb, and Zn were increased in patients with metastasis, but not in Se. As for colon tissue specimens, inconsistent levels were reported between studies, notably in Cu, Se, and Zn. No changes were reported for B and Ca levels. Most of the trace elements in the tissue specimens showed higher concentrations of Cr, Fe, K, Mg, P, Rb, S, and Si compared to Br. Conclusion: With the growing interest to understand the link between trace elements in carcinogenesis and the possible interactions, multi assessment analysis of a larger cohort of samples is necessary.
机译：背景：微量元素在结直肠癌（CRC）抑制和发育过程中起关键作用。这项系统的综述提供了病例对照研究的基本比较，重点研究了结直肠癌患者和对照人群中微量元素的浓度。方法：系统综述通过截至2017年6月24日的Medline和Cochrane两个数据库进行搜索。干预，比较和结果（PICO）。我们搜索了微量元素在癌症中的作用，并着重研究了CRC中的病例对照研究，以了解有无癌症患者中微量元素浓度的差异。结果：CRC患者的血清Ca，Cu，Mg，Mn，Se，Si和Zn浓度较低，而Co和S患者的CRC浓度较高。转移患者中Cd，Cr，Cu，Mg，Mn，Pb和Zn的浓度增加，而Se中没有。至于结肠组织标本，研究之间报道了不一致的水平，特别是在铜，硒和锌中。 B和Ca水平未见变化。与Br相比，组织样本中的大多数微量元素显示出更高的Cr，Fe，K，Mg，P，Rb，S和Si浓度。结论：随着人们越来越了解致癌作用中微量元素与可能的相互作用之间的联系，越来越多的样本需要进行多重评估分析。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号