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首页> 外文期刊>Italian Journal of Medicine >Adenoid ameloblastoma with dentinoid and cellular atypia: a rare case report
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Adenoid ameloblastoma with dentinoid and cellular atypia: a rare case report

机译：腺样细胞瘤细胞合并牙本质样和细胞异型性病：一例罕见病例报告

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摘要

Adenomatoid odontogenic tumor (AOT) is always a benign tumor with rare incidence of recurrence while ameloblastoma is the commonest gnathic tumor, which is always aggressive. Although co-occurrence of these lesions has been reported, this paper describes a homogenous combination of atypical AOT and ameloblastomatous proliferation with some malignant microscopic features. To date, a dozen cases or slightly more of this uncommon composite odontogenic tumor have been, quite correctly, reported in the literature under the designation of adenoid ameloblastoma . Of these, neither cellular atypia nor pleomorphism has been revealed. This extremely rare ameloblastomatous variant can pose a significant diagnostic challenge. Moreover, we report new findings of severe nuclear vacuolization, mitotic figures, cellular pleomorphism and nuclear hyperchromatism and chromatin peripheralization. However, the scattered occurrence of these was not sufficient for claiming a malignancy. To confirm, two immunohistochemical markers - calretinin and p53 - were recruited. Rendering itself to be suspicious, a rapt attention should be paid toward well interrogating this lesion histologically and immunohistochemically.
机译：腺瘤样牙源性肿瘤（AOT）始终是良性肿瘤，复发率极低，而成釉细胞瘤是最常见的咬伤性肿瘤，通常具有侵袭性。尽管已经报道了这些病变的同时发生，但本文描述了非典型AOT和成纤维细胞瘤增殖的均一组合，并具有一些恶性的微观特征。迄今为止，在文献中以腺样成釉细胞瘤的名称已经相当正确地报道了十几例这种罕见的复合牙源性肿瘤。其中，既没有发现细胞异型性也没有多态性。这种极为罕见的成釉细胞瘤变体可能带来重大的诊断挑战。此外，我们报告了严重的核空化，有丝分裂图，细胞多态性和核高色度和染色质外围化的新发现。然而，这些疾病的零散发生不足以声称是恶性的。为了证实这一点，募集了两种免疫组织化学标记物-钙网蛋白和p53。由于本身具有可疑性，因此应高度重视组织学和免疫组织化学方法对这种病变的询问。

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