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Adult onset Still’s disease presenting as fever of unknown origin: a case report with review of literature

机译:成人发作的斯蒂尔氏病表现为不明原因的发烧:一例报道并有文献复习

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Adult onset Still’s disease (AOSD) is a systemic inflammatory disease with exact etiology and pathogenesis yet to be discovered. AOSD, being an important cause of fever of unknown origin, is diagnosed after ruling out infections, malignancy and other rheumatologic diseases. It may present with fever without typical rash although typical triad is of fever, joint pain and rash. A 35-year-old previously healthy man was referred to our hospital with 6 months of fever, joint pain and weight loss. Examination and investigations revealed anemia, leukocytosis (predominant neutrophilia), lymphadenopathy, hepatomegaly, arthritis and evidence of interstitial lung disease with raised serum ferritin levels. Hematological disorders, infections and other rheumatologic diseases were excluded. The diagnosis of adult onset Still’s disease can be very difficult as there are no specific tests and diagnosis is based on symptom complex. AOSD presenting as fever of unknown origin could be a challenge for the physician to diagnose and manage timely.
机译:成人发作性斯蒂尔氏病(AOSD)是一种全身性炎症性疾病,其确切病因和发病机制尚待发现。 AOSD是不明原因的发烧的重要原因,在排除感染,恶性肿瘤和其他风湿性疾病后被诊断出。尽管典型的三联征是发烧,关节痛和皮疹,但它可能伴随发烧而没有典型的皮疹。一名35岁以前健康的人因发烧,关节痛和体重减轻而被转诊到我们医院。检查和调查显示贫血,白细胞增多(嗜中性粒细胞增多),淋巴结病,肝肿大,关节炎和间质性肺病的证据,血清铁蛋白水平升高。血液学疾病,感染和其他风湿病除外。由于没有特定的检查方法并且诊断是基于症状复杂的,因此诊断成人发作性Still病可能非常困难。 AOSD表现为不明原因的发烧可能是医师及时诊断和管理的挑战。

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