• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Italian Journal of Medicine >Evaluation of the pharmacoeconomics of drugs used for the treatment of long-term complications of sulfur mustard
【24h】

Evaluation of the pharmacoeconomics of drugs used for the treatment of long-term complications of sulfur mustard

机译：用于治疗硫芥子油长期并发症的药物的药效学评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sulfur Mustard (SM), a cytotoxic vesicant chemical warfare agent, has powerful irritant and blistering effects on the skin, eyes and respiratory tract. Since during the Iraq-Iran war, many Iranian soldiers and civilians were exposed to SM, there are several victims still suffering from long-term cutaneous, ocular and pulmonary complications. Currently, there is no definite treatment for long-term complications of SM, and only supportive medical care is being taken to minimize the symptoms. In this study, we compared the cost-effectiveness of common drugs that are used against long-term SM-induced complications in Iranian patients. In this review article, electronic databases were checked using the following key words: sulfur mustard, lung, skin, eye, cost-effectiveness, pharmacoeconomics and treatment. Abstracts of non-English papers and proceedings of congresses on SM were also assessed. Among the studied drugs, high-dose oral N-acetyl cysteine and long-acting inhaled corticosteroids against respiratory complications, topical corticosteroids and oral antihistamines against cutaneous complications and non-steroidal anti-inflammatory drugs and corticosteroids ophthalmic drops against ocular complications were found to be cost-effective. Usage of different drugs in the treatment of SM injuries in Iran, have imposed a significant economic burden to patients and their families because many drugs that are effective against chemical injuries are not covered by insurance. In addition, the development of more effective drugs in this field is considered as an urgent demand that should be noticed by the pharmaceutical industry.
机译：芥菜油（SM）是一种具有细胞毒性的药物化学战剂，对皮肤，眼睛和呼吸道具有强烈的刺激性和起泡作用。由于在伊拉克与伊朗战争期间，许多伊朗士兵和平民都暴露于SM中，因此仍有几名受害者长期遭受皮肤，眼和肺部并发症的折磨。目前，尚无明确的方法治疗SM的长期并发症，仅采取支持性医疗措施以最大程度地减轻症状。在这项研究中，我们比较了用于治疗伊朗患者中由SM引起的长期并发症的普通药物的成本效益。在这篇评论文章中，使用以下关键词检查了电子数据库：硫芥菜，肺，皮肤，眼睛，成本效益，药物经济学和治疗。还评估了非英语论文摘要和有关SM的大会记录。在研究的药物中，发现高剂量口服N-乙酰半胱氨酸和长效吸入皮质类固醇药物可预防呼吸道并发症，局部皮质类固醇药物和口服抗组胺药可预防皮肤并发症以及非甾体类抗炎药和皮质类固醇药物滴眼液可预防眼部并发症划算的。在伊朗，用于治疗SM伤害的不同药物的使用给患者及其家人带来了巨大的经济负担，因为许多对化学伤害有效的药物不在保险范围之内。另外，在该领域开发更有效的药物被认为是制药工业应注意的迫切需求。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号