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NT-proBNP correlates with the illness scores pneumonia severity index and CURB-65 in patients with pneumonia

机译：NT-proBNP与肺炎患者的疾病评分，肺炎严重程度指数和CURB-65相关

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Pneumonia severity index (PSI) and CURB-65 ( confusion, urea, respiratory rate, blood pressure, age ≥65 ) are used to estimate the severity and prognosis of patients with pneumonia. NT-proBNP is a marker of myocardial stress and of sepsis-induced myocardial depression and might be used to predict short and long-term survival in patients with pneumonia. Twenty-three patients [age 79±15 standard deviation (SD); M/F 8/15, CURB-65 2.2±0.9 SD, PSI 118±38 SD, procalcitonin 3.9±5 SD] with pneumonia hospitalized in our Internal Medicine Unit were retrospectively evaluated. NT-proBNP was measured in the first 72 h of hospitalization. CURB-65 and PSI were calculated and correlation with biomarkers investigated. NT-proBNP showed a moderate statistically significant correlation with both PSI and CURB-65 (NT-proBNP vs PSI, r=0.42, P<0.05, NT-proBNP vs CURB-65, r=0.46, P<0.05). These correlations were confirmed also when patients with a diagnosis of heart failure where excluded from the analysis, even if the correlation did not reach the statistical significance. NT-proBNP seems to well correlate with the illness scores PSI and CURB-65 and might be a reliable predictor of severity and survival in patients with pneumonia.
机译：肺炎严重程度指数（PSI）和CURB-65（精神错乱，尿素，呼吸频率，血压，年龄≥65岁）用于评估肺炎患者的严重程度和预后。 NT-proBNP是心肌压力和败血症引起的心肌抑制的标志物，可用于预测肺炎患者的短期和长期生存。 23例患者[年龄79±15标准差（SD）;回顾性分析了M / F 8/15，CURB-65 2.2±0.9 SD，PSI 118±38 SD，降钙素原3.9±5 SD]与我们内科医院住院的肺炎的关系。在住院的前72小时测量NT-proBNP。计算CURB-65和PSI，并研究其与生物标志物的相关性。 NT-proBNP与PSI和CURB-65均显示出中度统计学显着相关性（NT-proBNP与PSI，r = 0.42，P <0.05，NT-proBNP与CURB-65，r = 0.46，P <0.05）。当诊断为心力衰竭的患者被排除在分析范围之外时，即使相关性未达到统计显着性，这些相关性也得到了确认。 NT-proBNP似乎与疾病评分PSI和CURB-65密切相关，并且可能是肺炎患者严重程度和生存率的可靠预测指标。

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