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首页> 外文期刊>Italian Journal of Medicine >Increasing antimicrobial resistance of Helicobacter pylori infection among Saudi patients undergoing upper gastrointestinal endoscopy
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Increasing antimicrobial resistance of Helicobacter pylori infection among Saudi patients undergoing upper gastrointestinal endoscopy

机译：上消化道内窥镜检查沙特患者中幽门螺杆菌感染的耐药性增加

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There is growing concern about Helicobacter pylori resistance strains being the main agent contributing to eradication failure. In this study, we evaluated the prevalence and antimicrobial susceptibility trends of H. pylori over a period of time. Over a period of seven years a total of 384 biopsy specimens were sent to the microbiology department and evaluated for culturing H. pylori and assess its susceptibility. Biopsy specimens that cultured and where bacterial susceptibility was determined were regarded as H. pylori positive, and specimens that failed to culture were considered H. pylori negative. A total of 221 patients with H. pylori positive were assessed and antimicrobial susceptibility was determined. The overall prevalence of H. pylori infections among Saudis undergoing upper gastrointestinal endoscopy, with indicated specimens, was 57.6%. Antimicrobial susceptibility was evaluated; overall clarithromycin resistance was found to be 4.5% and metronidazole resistance 52.5%. The number of clarithromycin resistant strains has increased significantly from 2.5% in 2008 to 10% in 2014 (P<0.0001), and metronidazole resistance strains from 47% in 2008 to 65% in 2014 (P<0.001). H. pylori infection is very common among Saudi patients with peptic ulcer disease. Resistance of H. pylori against clarithromycin and metronidazole has increased significantly over the seven-year period. This suggests a need to monitor the annual antimicrobial susceptibility pattern.
机译：幽门螺杆菌抗性菌株是导致根除失败的主要因素，这引起了越来越多的关注。在这项研究中，我们评估了一段时间内幽门螺杆菌的患病率和抗菌药敏性趋势。在七年的时间里，总共384份活检标本被送往微生物学部门，并进行了幽门螺杆菌的培养和易感性评估。培养并确定细菌敏感性的活检标本被视为幽门螺杆菌阳性，培养失败的标本被视为幽门螺杆菌阴性。总共评估了221例H.pylori阳性患者，并确定了抗生素敏感性。接受上消化道内镜检查的沙特阿拉伯人中幽门螺杆菌感染的总体患病率为57.6％。评估了抗生素的敏感性;总体克拉霉素抗性为4.5％，甲硝唑抗性为52.5％。克拉霉素抗性菌株的数量从2008年的2.5％显着增加到2014年的10％（P <0.0001），甲硝唑抗性菌株从2008年的47％增加到2014年的65％（P <0.001）。在患有消化性溃疡疾病的沙特患者中，幽门螺杆菌感染非常普遍。七年来，幽门螺杆菌对克拉霉素和甲硝唑的耐药性显着增加。这表明需要监测年度抗菌药物敏感性模式。

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