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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Possible role of Mg2+ ion in the reaction of organophosphate (dichlorvos) with serine
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Possible role of Mg2+ ion in the reaction of organophosphate (dichlorvos) with serine

机译：Mg 2 + 离子在有机磷酸酯（敌敌畏）与丝氨酸反应中的可能作用

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摘要

Organophosphate pesticides (OPs) inhibit both true and pseudo-cholinesterases by reaction with the hydroxyl group of serine in their active sites. Poisoning with OPs is commonly seen in clinics. A common antidote for OP poisoning is atropine but, after ageing and OP dealkylation, even oximes could not be effective. It has been shown that oximes are not always useful in management of OP poisoning. On the other hand, magnesium has been found effective in both clinical and experimental studies. Studies to find more effective antidotes for OP poisoning are in progress. Presently, the possible role of magnesium ion in catalysis of reaction of dichlorvos (2,2-dichlorovinyl dimethyl phosphate, DDVP), a water-soluble OP, with serine is proposed. The hydroxyl group of serine could be a target to which DDVP can react. Nucleophilic attack of pralidoxime to DDVP was previously investigated. To confirm the idea, data were derived from recent and previous research on the role of magnesium in phosphoryl group transfer reactions. Possible reactions of serine and pralidoxime with DDVP in the absence and the presence of magnesium ion were separately investigated theoretically.
机译：有机磷酸酯农药（OPs）通过在其活性位点与丝氨酸的羟基反应来抑制真胆碱酯酶和假胆碱酯酶。在诊所中常见OP引起的中毒。常见的OP中毒解毒剂是阿托品，但老化和OP脱烷基后，即使肟也无效。已经表明，肟并不总是可用于治疗OP中毒。另一方面，已经发现镁在临床和实验研究中都是有效的。寻找用于OP中毒的更有效解毒剂的研究正在进行中。目前，提出了镁离子在催化水溶性水溶性OP的敌敌畏（2,2-二氯乙烯基二甲基磷酸酯，DDVP）与丝氨酸反应中的可能作用。丝氨酸的羟基可能是DDVP可以与之反应的目标。以前曾研究过吡咯肟对DDVP的亲核攻击。为了证实这一想法，数据来自镁合金在磷酰基转移反应中的作用的最新研究。理论上分别研究了在不存在和存在镁离子的情况下丝氨酸和普利肟肟与DDVP的可能反应。

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