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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Phlorotannin-incorporated mesenchymal stem cells and their promising role in osteogenesis imperfecta
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Phlorotannin-incorporated mesenchymal stem cells and their promising role in osteogenesis imperfecta

机译：结合了草绿单宁的间充质干细胞及其在成骨不全中的有希望的作用

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Osteogenesis imperfecta as the name suggests, is a bone disorder characterised by imperfect bone mineralisation and development. The key defect lies in the osteoblast–osteoid cycle, leading to insufficient calcification and consequently weak bones. Osteogenesis imperfecta patients are prone to fractures. Till date, numerous growth hormone/synthetic analogues have been used therapeutically in osteogenesis imperfecta patients and they do provide temporary relief, but not without numerous unwanted side effects. The intervention offered by such treatments is mainly at the symptomatic level, with temporary pain relief and some degree of mineralisation of available osteoids; but the root cause of the disease remains unattended. Such treatment modalities fail to promote mesenchymal stem cell osteogenic differentiation and tackle the fundamental deficiency of osteoids. This paper suggests a unique and hitherto unimplemented approach for treatment of osteogenesis imperfecta at the cellular level through application of a natural source, ‘Brown algae isolated phlorotannins’, which promote mesenchymal stem cell differentiation by increasing alkaline phosphatase activity, calcific mineralisation and total protein and collagen synthesis. This natural extract, when integrated directly with mesenchymal stem cells, will boost cellular differentiation into healthy bone-forming cells. The modality will strengthen the bone intrinsically and without the adverse reactions of routine pharmacotherapeutic agents.
机译：顾名思义，成骨不全症是一种以骨矿化和发育不全为特征的骨病。关键缺陷在于成骨细胞-类骨质循环，导致钙化不足，从而导致骨骼脆弱。成骨不全症患者容易骨折。迄今为止，成骨不全症患者已经在治疗上使用了许多生长激素/合成类似物，它们确实提供了暂时的缓解，但并非没有许多不良副作用。这种治疗的干预主要是对症治疗，可暂时缓解疼痛并在一定程度上使可用的类骨质矿化。但该病的根本原因仍未引起注意。这样的治疗方式不能促进间充质干细胞成骨分化并不能解决类骨质的根本缺陷。本文提出了一种独特的，迄今尚未实现的方法，该方法通过应用天然来源“棕藻分离的果单宁”在细胞水平上治疗成骨不全症，该方法可通过增加碱性磷酸酶活性，钙化矿化和总蛋白和胶原蛋白合成。这种天然提取物与间充质干细胞直接整合后，将促进细胞分化为健康的骨形成细胞。这种方式将内在地增强骨骼，而不会出现常规药物治疗剂的不良反应。

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