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Physical stress may result in growth suppression and pubertal delay in working boys

机译:身体压力可能导致工作男孩的生长受到抑制和青春期延迟

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Child labour is an immense problem in Pakistan. As labour boys are put under persistent/severe physical stress, we hypothesised, that it may result in higher levels of cortisol and exhaust glycogen, fats and protein. Depletion of fats may result in lower body weight, and insufficient leptin concentrations could excite gonadotropic releasing hormone (GnRH) at normal time of puberty in working boys. Moreover, lower testosterone levels in working boys, due to delayed puberty, may result in suppression of somatotropic axis. Short/weak stature and failure of onset of puberty may cause poor performance, inferiority complex and psychological disorders. Therefore, the present study is designed to find out the timing of onset of puberty in working boys. The study will include 10–18 years of working boys as case and non-working boys of the same age group as control. Working boys will be labour boys, while the control group will not be involved in physical work. A questionnaire will be used to record socioeconomic status, major diseases, nutritional status, type and duration of work and family history of puberty, growth and obesity of subjects. Boys with familial history of pubertal delay, obesity, malnutrition, mental disorders, haematological diseases and severe/chronic diseases will be excluded. The intensity of physical working stress will be determined by a grading scale. The anthropometric data including height, weight, body mass index (BMI), bone age and tests of adiposity will be collected from subjects. The stages of pubertal onset will be determined by Tanner staging. Serum concentrations of hormones of growth, thyroid, adrenal, brain–gut and gonadal axis will be determined in non-working and working boys. Physical and hormonal tests of the working boys and the comparison with non-working boys are sufficient to test the idea.
机译:在巴基斯坦,童工是一个巨大的问题。我们假设,由于劳动男孩受到持续的/严重的身体压力,这可能导致更高水平的皮质醇和排出的糖原,脂肪和蛋白质。脂肪的消耗可能导致体重降低,瘦素的浓度不足会在正常工作的青春期男孩中激发促性腺激素释放激素(GnRH)。此外,由于青春期延迟,工作男孩的睾丸激素水平较低,可能导致生长激素的抑制。身材矮小/虚弱以及青春期发作失败可能会导致表现不佳,自卑感和心理障碍。因此,本研究旨在找出工作男孩青春期发作的时机。该研究将包括10-18岁的在职男童作为案例,在同年龄组的非在职男童作为对照。工作男孩将是劳动男孩,而对照组将不参与体力劳动。问卷将用于记录社会经济状况,主要疾病,营养状况,工作类型和时间以及青春期的家族史,受试者的成长和肥胖。具有青春期延迟,肥胖,营养不良,精神疾病,血液病和严重/慢性疾病的家族史的男孩将被排除在外。物理工作压力的强度将由等级决定。人体测量数据包括身高,体重,体重指数(BMI),骨骼年龄和肥胖测试。青春期的发作阶段将由Tanner分期确定。在非工作和工作的男孩中,将确定生长激素,甲状腺,肾上腺,脑肠和性腺轴的血清浓度。对在职男生的身体和激素测试以及与非在职男生的比较足以证明这一想法。

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