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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Proposing boric acid as an antidote for aluminium phosphide poisoning by investigation of the chemical reaction between boric acid and phosphine
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Proposing boric acid as an antidote for aluminium phosphide poisoning by investigation of the chemical reaction between boric acid and phosphine

机译：通过研究硼酸和膦的化学反应，提出硼酸作为解磷铝中毒的解毒剂

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Aluminium phosphide (AlP) is a storage fumigant pesticide, which is used to protect stored grains especially from insects and rodents. It releases phosphine (PH3) gas, a highly toxic mitochondrial poison, in contact with moisture, particularly if acidic. Although the exact mechanism of action is unknown so far, the major mechanism of PH3 toxicity seems to be the inhibition of cytochrome-c oxidase and oxidative phosphorylation which eventually results in adenosine triphosphate (ATP) depletion and cell death. Death due to AlP poisoning seems to be as a result of myocardial damage. No efficient antidote has been found for AlP poisoning so far, and unfortunately, most of the poisoned human cases die. PH3, like ammonia (NH3), is a Lewis base with a lone-pair electron. However, boric acid (B(OH)3) is a Lewis acid with an empty p orbital. It is predicted that lone-pair electron from PH3 is shared with the empty p orbital from B(OH)3 and a compound forms in which boron attains its octet. In other words, PH3 is trapped and neutralised by B(OH)3. The resulting polar reaction product seems to be excretable by the body due to hydrogen bonding with water molecules. The present article proposes boric acid as a non-toxic and efficient trapping agent and an antidote for PH3 poisoning by investigating the chemical reaction between them.
机译：磷化铝（AlP）是一种储存熏蒸农药，用于保护储存的谷物，尤其是免受昆虫和啮齿动物的伤害。它会与湿气（特别是在酸性环境中）接触时释放出磷化氢（PH 3 ）气体，这是一种剧毒的线粒体毒物。尽管目前尚不清楚确切的作用机制，但PH 3 毒性的主要机制似乎是抑制细胞色素c氧化酶和氧化磷酸化，最终导致三磷酸腺苷（ATP）消耗和细胞死亡。死亡。 AlP中毒导致的死亡似乎是心肌损伤的结果。迄今为止，尚未发现有效的解毒剂来预防AlP中毒，不幸的是，大多数中毒的人类病例都已死亡。像氨（NH 3 ）一样，PH 3 是具有孤对电子的路易斯碱。然而，硼酸（B（OH） 3 ）是具有空p轨道的路易斯酸。据预测，PH 3 的孤对电子与B（OH） 3 的空p轨道共享，并且形成硼达到其八位字节的化合物形式。换句话说，PH 3 被B（OH） 3 捕获并中和。所产生的极性反应产物似乎由于与水分子的氢键而被人体排泄。本文通过研究硼酸作为无毒，有效的捕集剂和PH 3 中毒的解毒剂，提出了硼酸的无毒捕集剂。

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