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Evaluation of maternal thyroid autoimmune status in gestational trophoblastic disorders

机译:妊娠滋养细胞疾病孕妇甲状腺自身免疫状态的评估

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Evaluation of maternal thyroid autoimmune status in gestational trophoblastic disorders Erbil Karaman , Orkun ?etin, Numan ?im, Ali Kolusar?, Seyithan Güler, Recep Y?ld?zhan, ?smet Alk??, Han?m Güler ?ahin Yuzuncu Yil University Medical Faculty Department Of Obstetric And Gynecology INTRODUCTION: To investigate the maternal autoimmune status of patients with molar pregnancies METHODS: The study was conducted at Yuzuncu Y?l University, Department of Obstetrics and Gynecology between January 2012 and June 2016. The medical records patients who were diagnosed and followed for complete and partial molar pregnancies were reviewed retrospectively. The data of patients who were studied for maternal thyroid auto-antibodies including Anti-Thyroid peroxidase(TPO) and Anti-Tyroglobulin(Tg) were included in the study. RESULTS: The mean maternal age of complete molar pregnancies were significantly higher than partial molar pregnancies (p: 0.010). There was no significant difference in terms of beta-HCG, TSH and free T4 values between two groups (p: 0.815, p: 0.204 and 0.072, respectively). None of the patients were anti- TPO positive in the study. There was no significant difference in anti-thyroglobulin positivity between two groups (p: 0.950). DISCUSSION AND CONCLUSION: Maternal thyroid autoantibody status did not showed any difference in partial and complete molar pregnancies. Thyroid dysfunction seen in molar pregnancies seems to be due to the stimulation of follicular cell receptors with HCG rather than auto-antibodies against thyroid gland.
机译:妊娠滋养细胞疾病孕妇的甲状腺自身免疫状态评估Erbil Karaman,Orkun?etin,Numan?im,Ali Kolusar?,SeyithanGüler,Recep Y?ld?zhan,?smet Alk ??,Han?mGüler?ahin Yuzuncu Yil University简介:调查磨牙妊娠患者的母体自身免疫状况方法:该研究于2012年1月至2016年6月在尤祖库耶尔大学妇产科进行。病历记录如下:进行诊断和随访,以进行完全和部分磨牙妊娠的回顾性回顾。研究的患者母体甲状腺自身抗体包括抗甲状腺过氧化物酶(TPO)和抗甲状腺球蛋白(Tg)的患者数据也包括在内。结果:完全磨牙妊娠的平均孕妇年龄显着高于部分磨牙妊娠(p:0.010)。两组之间在β-HCG,TSH和游离T4值方面无显着差异(分别为p:0.815,p:0.204和0.072)。在该研究中,没有患者抗-TPO阳性。两组之间的抗甲状腺球蛋白阳性无显着差异(p:0.950)。讨论与结论:母体甲状腺自身抗体状态在部分和完全磨牙妊娠中未显示任何差异。在磨牙妊娠中发现的甲状腺功能异常似乎是由于HCG刺激了卵泡细胞受体,而不是针对甲状腺的自身抗体。

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