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Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

机译:小儿年龄的维生素D:意大利儿科学会和意大利预防与社会儿科学会与意大利儿科医生联合会达成共识

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Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur. Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.
机译:维生素D在钙磷代谢的调节中起着关键作用,尤其是在小儿时期,这时可能发生营养性bone病和受损的骨量获取。除了其历史上的骨骼功能外,最近几年还证明维生素D直接或间接调节多达1250个基因,发挥所谓的骨骼外作用。实际上,最近的数据表明维生素D在几种病理状况(包括传染性,变态反应性和自身免疫性疾病)的发病机理中可能发挥作用。因此,维生素D缺乏症不仅可能影响肌肉骨骼健康,而且可能影响广泛的急性和慢性疾病。目前,意大利儿童和青少年中维生素D缺乏症的患病率很高,并且缺乏有关儿童年龄补充维生素D的国家建议。意大利预防与社会儿科协会的一个专家小组审查了现有文献,重点关注补充维生素D的随机对照试验,从而为婴儿,儿童和青少年提供了一种补充维生素D的实用方法。

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