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首页> 外文期刊>Eastern Mediterranean Health Journal: Al-Magallat al-Sihhiyyat li-Sarq al-Mutawassit >Prevalence of type b Haemophilus influenzae and antibiotic resistance in 52 clinical isolates in north Lebanon
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Prevalence of type b Haemophilus influenzae and antibiotic resistance in 52 clinical isolates in north Lebanon

机译：黎巴嫩北部52株临床分离株中b型流感嗜血杆菌的流行和耐药性

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The aim of this study was to determine the capsular typing and type b prevalence of clinical Haemophilus influenzae strains in north Lebanon in both invasive and non-invasive disease and to determine the susceptibility pattern and the mechanism of resistance to β-lactams [β-lactamase–producing strains and β-lactamase–negative ampicillin resistant (BLNAR) strains]. Fifty-two strains of clinical H. influenzae were isolated from 312 clinical specimens; the resistance pattern to β-lactams of these strains was determined by using the disc diffusion and E-test methods followed by molecular methods such as PCR of bla TEM et bla ROB genes. Nine (17.4%) of the 52 strains were resistant to ampicillin; all of them produced type TEM-1 β-lactamase. In the susceptible strains 15.3% were not fully susceptible to β-lactams or considered low BLNAR strains. Slide agglutination serotyping showed that 30.7% of the strains were type b.
机译：这项研究的目的是确定黎巴嫩北部侵袭性和非侵袭性疾病中临床流感嗜血杆菌菌株的荚膜类型和b型患病率，并确定对β-内酰胺[β-内酰胺酶]的敏感性模式和耐药机制产菌株和β-内酰胺酶阴性的氨苄青霉素抗性（BLNAR）菌株]。从312份临床标本中分离出52株临床流感嗜血杆菌。通过使用圆盘扩散法和E-test法，然后通过分子方法，例如bla TEM和bla ROB基因的PCR，确定这些菌株对β-内酰胺的抗性模式。 52个菌株中有9个（17.4％）对氨苄西林有抗药性;他们都产生了TEM-1型β-内酰胺酶。在易感菌株中，有15.3％的患者对β-内酰胺类药物不完全敏感或被认为是低BLNAR菌株。载玻片凝集血清分型显示30.7％的菌株是b型。

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