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首页> 外文期刊>EBioMedicine >Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development
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Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development

机译：匹配和预测个体龋齿发展的变形链球菌黏附素生物型

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Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries development. The adhesin types were measured in whole saliva by qPCR in 452 12-year-old Swedish children and related to caries at baseline and prospectively at a 5-year follow-up. Strains isolated from the children were explored for genetic and phenotypic properties. The presence of SpaP B and Cnm subtypes coincided with increased 5-year caries increment, and their binding to DMBT1 and saliva correlated with individual caries scores. The SpaP B subtypes are enriched in amino acid substitutions that coincided with caries and binding and specify biotypes of S. mutans with increased acid tolerance. The findings reveal adhesin subtypes of S. mutans that match and predict individual differences in caries development and provide a rationale for individualized oral care.
机译：影响数十亿人的龋齿是一种慢性感染性疾病，涉及变形链球菌，但它不能很好地预测个体龋齿的发展。因此，我们研究了对宿主DMBT1（即SpaPA，B或C）和蔗糖（即Cnm，Cbm）具有蔗糖依赖性粘附的变形链球菌的粘附素类型是否匹配，并预测了龋齿发育的个体差异。通过qPCR在452名12岁的瑞典儿童中测量了唾液中的黏附素类型，这些黏附素的类型与基线和未来5年随访中的龋齿有关。探索了从孩子身上分离的菌株的遗传和表型特性。 SpaP B和Cnm亚型的存在与5年龋齿增加增加相吻合，它们与DMBT1和唾液的结合与个体龋齿评分相关。 SpaP B亚型富含与龋齿和结合相吻合的氨基酸取代，并具有更高的耐酸性，可确定变形链球菌的生物型。该发现揭示了变形链球菌的粘附素亚型，其匹配并预测龋齿发展中的个体差异，并为个体化口腔护理提供了依据。

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