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首页> 外文期刊>Eastern Journal of Medicine >The activity of topical coenzyme Q10 (ubiquinol) in burned rats: Results from an experimental study
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The activity of topical coenzyme Q10 (ubiquinol) in burned rats: Results from an experimental study

机译：烧伤大鼠局部辅酶Q10（泛醇）的活性：一项实验研究的结果

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The activity of topical coenzyme Q10 (ubiquinol) in burned rats: Results from an experimental study Ceren Canbey G?ret sup1/sup, Asl? Kirazsup2/sup, Nuri Emrah G?retsup3/sup, Sevilay O?uz K?l??sup4/sup, ?mer Faruk ?zkansup5/sup, Muammer Karaayvazsup6/sup sup1/supDepartment of Surgical Pathology, Health Sciences University, Sancaktepe Research and Education Hospital, Istanbul, Turkey sup2/supDepartments of Microbiology, Onsekiz Mart University Research and Application Hospital, Canakkale, Turkey sup3/supDepartment of General Surgery, Health Sciences University, Kartal Dr Lütfi K?rdar Research and Education Hospital, Istanbul, Turkey sup4/supDepartment Dermatology, Onsekiz Mart University Research and Application Hospital, Canakkale, Turkey sup5/supDepartment of General Surgery, Health Sciences University, Umraniye Research and Education Hospital, Istanbul, Turkey sup6/supDepartment General Surgery, Onsekiz Mart University Research and Application Hospital, Canakkale, Turkey INTRODUCTION: The objective of this study was to investigate the effectiveness of topically applied coenzyme Q10 (CoQ10) (ubiquinol) for wound healing in rats with experimentally induced burn injuries. METHODS: A total of 27 rats was divided into three groups, and administered general anesthesia. No further intervention was performed for Group 1 (Control). Hot water (95°C) was applied to rats in Groups 2 and 3 for 10 seconds. The rats in Group 2 received silver sulfadiazine, whereas those in Group 3 received topical CoQ10. Biopsy specimens were obtained at days 3 and 10. RESULTS: In the group treated with CoQ10 (Group 3), there was not statistically meaningful difference among Days 3 and 10 in terms of inflammation and epidermal/vascular/collagen damage. In terms of edema, there was a statistically meaningful distinction among the CoQ10 group (Group 3) at Day 10 and the silver sulfadiazine group (Group 2) at Day 3. In terms of oxygen radicals, there was a statistically meaningful difference among the CoQ10 group and the silver sulfadiazine group at Day 10. DISCUSSION AND CONCLUSION: This investigation did not demonstrate a beneficial role of treatment with CoQ10 for the healing of burn wounds for most parameters. But in the long term (10 day); immunohistochemical analysis performed to determine edema and oxidative stress showed that treatment with CoQ10 reduced the levels of oxygen radicals in biopsies. The limitation of our study is that the duration is limited to 10 days. For this reason longer term studies were required.
机译：烧伤大鼠局部辅酶Q10的活性：一项实验研究的结果Ceren Canbey G？ret 1 ，Asl？基拉兹 2 ，努里·埃姆拉·格莱特 3 ，塞维尔·奥乌兹·克鲁斯K？l ?? 4 、?法鲁克？zkan 5 ，Muammer Karaayvaz 6 1 土耳其伊斯坦布尔市Sancaktepe研究与教育医院卫生科学大学外科病理学系 2 土耳其恰纳卡莱市Onsekiz Mart大学研究与应用医院微生物学系 3 健康科学大学普通外科，土耳其伊斯坦布尔KartalLütfiK？rdar研究与教育医院 4 土耳其恰纳卡莱市Onsekiz Mart大学研究与应用医院皮肤科 5 土耳其伊斯坦布尔Umraniye研究与教育医院卫生科学大学普通外科 6 土耳其，恰纳卡莱，Onsekiz Mart大学研究与应用医院普​​外科Q10（CoQ10）（泛醇）酶用于实验性烧伤大鼠的伤口愈合。方法：将27只大鼠分为三组，进行全身麻醉。第一组（对照）未进行进一步干预。在第2组和第3组中，将热水（95°C）应用于大鼠10秒钟。第2组的大鼠接受磺胺嘧啶银，而第3组的大鼠则接受局部CoQ10。结果：在第3天和第10天获得了活检标本。结果：在用CoQ10治疗的组（第3组）中，第3天和第10天在炎症和表皮/血管/胶原蛋白损伤方面没有统计学意义的差异。就水肿而言，第10天的CoQ10组（第3组）和第3天的磺胺嘧啶银组（第2组）在统计学上有意义的区别。就氧自由基而言，CoQ10之间在统计学上有意义的差异组和磺胺嘧啶银组在第10天进行了讨论。但是从长远来看（10天）;进行免疫组化分析以确定水肿和氧化应激反应表明，辅酶Q10处理可降低活检组织中氧自由基的水平。我们研究的局限性是持续时间限制为10天。因此，需要进行长期研究。

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