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首页> 外文期刊>Eastern Journal of Medicine >The value of F-18 FDG PET/CT for detecting primary foci in the metastatic cancer of unknown primary origin
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The value of F-18 FDG PET/CT for detecting primary foci in the metastatic cancer of unknown primary origin

机译：F-18 FDG PET / CT在原发性未知来源转移癌中检测原发灶的价值

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The value of F-18 FDG PET/CT for detecting primary foci in the metastatic cancer of unknown primary origin Erdem Sürücü 1 , Melike ?entay A?c?o?lu 2 , Tar?k ?eng?z 3 , Yusuf Demir 1 , Hatice Durak 2 1 2 3 Cancers of unknown primary origin (CUP) have poor prognosis and the median survival for patients with CUP is approximately 1 year. This survival can be extended by the identification of the primary origin and treating with specific therapy. F-18 FDG PET/CT scans of 75 patients (39 female, 36 male, mean age 60 ±12) with CUP referred to our clinic between January 2009 and January 2011 were evaluated retrospectively. Whole body images were obtained 60 minutes after the injection of approximately 370 MBq (10 mCi) F-18 FDG by PET/CT (Gemini-TOF-Philips). Emission scans were obtained for 1.5 min per bed position and transmission scans were obtained with low dose CT using 50 mA and 120 kvp. The tumor was identified histopathologically in 58 of 75 patients. 4 of 58 patients were treated as CUP. 17 of 75 patients could not be followed, so final diagnosis could not be made. In 54 patients, the primary was identified as 17 lung, 8 colorectal, 7 breast, 3 stomach, 3 pancreas, 2 endometrial, 2 nasopharynx, 2 gallbladder cancers, 2 lymphoma, 2 peritoneum, 1 maxillary sinus, 1 salivary gland carcinoma, 1 brain tumor, 1 leiomyosarcoma, 1 ovary cancer and 1 multiple myeloma. If reports are considered, F-18 FDG PET/CT helped to detect primary origin in 65% of these 58 patients, 38 of 54 primary sites were true positive (70%). There were 6 false positive sites (10.3%), 16 false negative (27.5%) results in F-18 FDG PET/CT. After the retrospective evaluation of the false negative patients, we have realized that primary sites were ignored in 5 of 14 patients, so actually F-18 FDG PET/CT helped in 74% of the patients showing 43 of 54 primary sites (80%). In first evaluation, F-18 FDG PET/CT missed 2 breast cancers, 1 lymphoma, 1 colon cancer and 1 intra maxillary sinus cancer. F-18 FDG PET/CT is an important imaging tool for detecting primary origin in the patients with CUP. F-18 FDG PET/CT helped in 74% of the patients showing the primary sites. In the patients with CUP, lung, breast, colon and the physiologic uptake areas should be scrutinized carefully for any tumor location.
机译：F-18 FDG PET / CT对未知来源的原发性转移癌ErdemSürücü 1 ，Melike？entay A？c？o？lu 2 ，Tar？k？eng？z 3 ，优素福·德米尔 1 ，哈蒂斯·杜拉克 2 1 2 3 未知原发性癌（CUP）的预后较差，CUP患者的中位生存期约为1年。可以通过鉴定主要来源并用特定疗法治疗来延长生存期。回顾性分析了2009年1月至2011年1月间转诊至我院的75例CUP患者（男39例，男36例，平均年龄60±12）的F-18 FDG PET / CT扫描。在通过PET / CT（Gemini-TOF-Philips）注射约370 MBq（10 mCi）F-18 FDG后60分钟获得全身图像。在每个床位上进行1.5分钟的发射扫描，并使用50 mA和120 kvp的低剂量CT进行透射扫描。在75例患者中有58例在组织病理学上被发现。 58例中有4例作为CUP治疗。 75位患者中有17位无法追踪，因此无法做出最终诊断。在54例患者中，原发性被确定为17肺，8个结直肠，7个乳房，3个胃，3个胰腺，2个子宫内膜，2个鼻咽，2个胆囊癌，2个淋巴瘤，2个腹膜，1个上颌窦，1个唾液腺癌，1个脑肿瘤，平滑肌肉瘤1例，卵巢癌1例和多发性骨髓瘤1例。如果考虑报告，F-18 FDG PET / CT有助于在这58名患者中的65％中检测出主要来源，在54个主要部位中有38个是真正阳性（70％）。 F-18 FDG PET / CT中有6个假阳性位点（10.3％），有16个假阴性位点（27.5％）。在对假阴性患者进行回顾性评估后，我们意识到14名患者中有5名忽略了原发部位，因此实际上F-18 FDG PET / CT在显示54名原发部位中的43名的患者中有74％（80％） 。在首次评估中，F-18 FDG PET / CT漏诊了2例乳腺癌，1例淋巴瘤，1例结肠癌和1例上颌窦窦癌。 F-18 FDG PET / CT是检测CUP患者主要来源的重要成像工具。 F-18 FDG PET / CT帮助74％的患者显示了主要部位。在有银联的患者中，应仔细检查肺，乳腺，结肠和生理摄取区域的任何肿瘤位置。

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