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首页> 外文期刊>Eastern Journal of Medicine >Diagnostic accuracy of IgA anti-tissue transglutaminase in celiac disease in Van-Turkey
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Diagnostic accuracy of IgA anti-tissue transglutaminase in celiac disease in Van-Turkey

机译：IgA抗组织转谷氨酰胺酶在Van-Turkey腹腔疾病中的诊断准确性

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Diagnostic accuracy of IgA anti-tissue transglutaminase in celiac disease in Van-Turkey Yasemin Bayram 1 , Mehmet Parlak 1 , Cenk Aypak 2 , ?rfan Bayram 3 , Deniz Y?lmaz 3 , Aytekin ??kman 4 1 2 3 4 Although the IgA anti-tissue transglutaminase test (IgA anti-Ttg) has been recommended as the first step in the diagnosis of celiac disease (CD), there are controversial data about the real accuracy of the test in clinical practice. Therefore we evaluated the sensitivity and specificity of the IgA anti-Ttg in a group of patients who were suspected of having CD. The study was performed at Van Training and Research Hospital, Van-Turkey. Details of patients in whom the IgA anti-Ttg was requested from January 2009 to April 2012 were obtained from databases. Duplicate requests were excluded. Histopathologic examination of duodenal biopsies and serologic evaluations were compared. A total of 1614 IgA anti-Ttg were requested from different patients. In all, 49.6% of requests were in females and 29.8% from children under the age of sixteen. A total of 192 (11.9%) requests were found to be positive. Duodenal biopsies were performed to 61 (31.8%) of seropositive patients. The overall sensitivity and specificity of IgA anti-Ttg were 93.3% and 9.5%. Our data have revealed that clinicians should be aware of solely relying on the results of the IgA anti-Ttg test could result in unnecessary diagnostic procedures and treatments.
机译：IgA抗组织转谷氨酰胺酶在Van-Turkey Yasemin Bayram 1 ，Mehmet Parlak 1 ，Cenk Aypak 2 、? rfan的腹腔疾病中的诊断准确性Bayram 3 ，Deniz Y？lmaz 3 ，Aytekin ?? kman 4 1 2 3 4 尽管建议将IgA抗组织转谷氨酰胺酶测试（IgA anti-Ttg）作为诊断乳糜泻（CD）的第一步，有关临床实践中测试的真实准确性的有争议数据。因此，我们在一组怀疑患有CD的患者中评估了IgA抗Ttg的敏感性和特异性。这项研究是在Van-Turkey的Van Training and Research Hospital进行的。从数据库中获得了从2009年1月至2012年4月需要IgA抗Ttg的患者的详细信息。重复的请求被排除在外。比较十二指肠活检的组织病理学检查和血清学评估。不同患者共要求1614 IgA抗Ttg。总共有49.6％的请求来自女性，而29.8％的请求来自16岁以下的儿童。共有192（11.9％）个请求为阳性。对61名（31.8％）血清反应阳性患者进行了十二指肠活检。 IgA抗Ttg的总体敏感性和特异性分别为93.3％和9.5％。我们的数据表明，临床医生应意识到仅依靠IgA抗Ttg测试的结果可能会导致不必要的诊断程序和治疗。

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